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The Value of Elastic Modulus Index as a Novel Surrogate Marker for Cardiovascular Risk Stratification by Dimensional Speckle-Tracking Carotid Ultrasonography

DC FieldValueLanguage
dc.contributor.author심지영-
dc.contributor.author윤지현-
dc.contributor.author장혁재-
dc.contributor.author정남식-
dc.contributor.author조인정-
dc.contributor.author홍그루-
dc.date.accessioned2017-10-26T07:47:57Z-
dc.date.available2017-10-26T07:47:57Z-
dc.date.issued2016-
dc.identifier.issn1975-4612-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152523-
dc.description.abstractBACKGROUND: Carotid intima media thickness (CIMT) and the presence of carotid plaque have been used for risk stratification of cardiovascular disease (CVD). To date, however, the association between multi-directional functional properties of carotid artery and CVD has not been fully elucidated. We sought to explore the multi-directional mechanics of the carotid artery in relation to cardiovascular risk. METHODS: Four hundred one patients who underwent carotid ultrasound were enrolled between January 2010 and April 2013. A high risk of CVD was defined as more than 20% of 10-year risk based on the Framingham risk score. Using a speckle-tracking technique, the longitudinal and radial movements were analyzed in the B-mode images. Peak longitudinal and radial displacements, strain and strain rate were also measured. Beta stiffness and elastic modulus index were calculated from the radial measurements. RESULTS: Of the overall sample, 13% (52) of patients comprised the high-risk group. In multivariate logistic regression, CIMT and elastic modulus index were independently associated with a high-risk of CVD {odds ratio (OR): 1.810 [95% confidence interval (CI) 1.249-2.622] and OR: 1.767 (95% CI: 1.177-2.652); p = 0.002, 0.006, respectively}. The combination of CIMT and elastic modulus index correlated with a high-risk of CVD more so than CIMT alone. CONCLUSION: The elastic modulus index of the carotid artery might serve as a novel surrogate marker of high-risk CVD. Measurement of the multi-directional mechanics of the carotid artery using the speckle tracking technique has potential for providing further information over conventional B-mode ultrasound for stratification of CVD risk.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean, English-
dc.publisherKorean Society of Echocardiography-
dc.relation.isPartOfJournal of Cardiovascular Ultrasound-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Value of Elastic Modulus Index as a Novel Surrogate Marker for Cardiovascular Risk Stratification by Dimensional Speckle-Tracking Carotid Ultrasonography-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJi Hyun Yoon-
dc.contributor.googleauthorIn-Jeong Cho-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorJi Min Sung-
dc.contributor.googleauthorJinyong Lee-
dc.contributor.googleauthorHojin Ryoo-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi10.4250/jcu.2016.24.3.215-
dc.contributor.localIdA02609-
dc.contributor.localIdA03490-
dc.contributor.localIdA03585-
dc.contributor.localIdA03892-
dc.contributor.localIdA04386-
dc.contributor.localIdA02213-
dc.relation.journalcodeJ01298-
dc.relation.journalsince2006~-
dc.identifier.pmid27721952-
dc.relation.journalbefore~2005 Journal of the Korean Society of Echocardiography (한국심초음파학회지)-
dc.subject.keywordCardiovascular disease-
dc.subject.keywordCarotid artery-
dc.subject.keywordElastic modulus-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameYoon, Ji Hyun-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCho, In Jeong-
dc.contributor.alternativeNameHong, Geu Ru-
dc.contributor.affiliatedAuthorYoon, Ji Hyun-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorCho, In Jeong-
dc.contributor.affiliatedAuthorHong, Geu Ru-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.citation.volume24-
dc.citation.number3-
dc.citation.startPage215-
dc.citation.endPage222-
dc.identifier.bibliographicCitationJournal of Cardiovascular Ultrasound, Vol.24(3) : 215-222, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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