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Terahertz reflectometry imaging for low and high grade gliomas

Authors
 Young Bin Ji  ;  Seung Jae Oh  ;  Seok-Gu Kang  ;  Jung Heo  ;  Sang-Hoon Kim  ;  Yuna Choi  ;  Seungri Song  ;  Hye Young Son  ;  Se Hoon Kim  ;  Ji Hyun Lee  ;  Seung Joo Haam  ;  Yong Min Huh  ;  Jong Hee Chang  ;  Chulmin Joo  ;  Jin-Suck Suh 
Citation
 Scientific Reports, Vol.6 : 36040, 2016 
Journal Title
 Scientific Reports 
ISSN
 2045-2322 
Issue Date
2016
MeSH
Animals ; Glioma/diagnostic imaging* ; Glioma/metabolism ; Glioma/pathology ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms, Experimental/diagnostic imaging* ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Terahertz Imaging/methods*
Abstract
Gross total resection (GTR) of glioma is critical for improving the survival rate of glioma patients. One of the greatest challenges for achieving GTR is the difficulty in discriminating low grade tumor or peritumor regions that have an intact blood brain barrier (BBB) from normal brain tissues and delineating glioma margins during surgery. Here we present a highly sensitive, label-free terahertz reflectometry imaging (TRI) that overcomes current key limitations for intraoperative detection of World Health Organization (WHO) grade II (low grade), and grade III and IV (high grade) gliomas. We demonstrate that TRI provides tumor discrimination and delineation of tumor margins in brain tissues with high sensitivity on the basis of Hematoxylin and eosin (H&E) stained image. TRI may help neurosurgeons to remove gliomas completely by providing visualization of tumor margins in WHO grade II, III, and IV gliomas without contrast agents, and hence, improve patient outcomes.
Files in This Item:
T201604517.pdf Download
DOI
10.1038/srep36040
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Oh, Seung Jae(오승재)
Lee, Ji Hyun(이지현) ORCID logo https://orcid.org/0000-0002-9223-9478
Chang, Jong Hee(장종희)
Ji, Young Bin(지영빈)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152512
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