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Immunotoxicity of metal oxide and metal nanoparticles and animal models to evaluate immunotoxicity of nanoparticles

Authors
 HanGoo Kang  ;  Jiyoung Jang  ;  In-Hong Choi 
Citation
 Current Bionanotechnology, Vol.2(2) : 84-90, 2016 
Journal Title
 Current Bionanotechnology 
ISSN
 2213-5294 
Issue Date
2016
Keywords
Nanoparticles ; metal ; metal oxide ; immunotoxicity ; animal model
Abstract
Since metal (silver and gold) and metal oxide (TiO2, ZnO, SiO2) nanoparticles (NPs) are widely used in diagnostics, therapeutics, and commercial products, specialized immuno-toxicity studies are necessary to ensure their safe use in humans. In this article, we review the immunological toxicity of engineered nanomaterials (ENMs), including metal oxide and metal NPs, and suggest animal models of immunological disease suited to study the immunological effects of NPs. Administration of NPs at subtoxic doses in animals with a background of immunological diseases, especially those with allergic or inflammatory diseases, will accelerate our understanding of the precise immunotoxicity and immunestimulatory effects of NPs following real-life exposures.
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T201604509.pdf Download
DOI
10.2174/2213529402666160601112729
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152509
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