99 95

Cited 4 times in

Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia

DC FieldValueLanguage
dc.contributor.author김지은-
dc.contributor.author유철주-
dc.contributor.author이승태-
dc.contributor.author최종락-
dc.date.accessioned2017-10-26T07:45:31Z-
dc.date.available2017-10-26T07:45:31Z-
dc.date.issued2016-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152479-
dc.description.abstractBACKGROUND: Intrachromosomal amplification of chromosome 21 (iAMP21) is known to be associated with poor prognosis in B-cell ALL (B-ALL). To determine the frequency and clinical characteristics of iAMP21 in Korean B-ALL patients, we performed FISH and multiplex ligation-dependent probe amplification (MLPA) analyses. METHODS: A total of 102 childhood B-ALL patients were screened with ETV6-RUNX1 FISH probes (Abbott Molecular, USA). The presence of an iAMP21 was confirmed by using MLPA P327 iAMP21-ERG probemix (MRC Holland, The Netherlands). RESULTS: iAMP21 was detected in one of the screened B-ALL patients (1/102 patients, 1.0%) who presented the ALL immunophenotype and complex karyotype at initial diagnosis. The patient relapsed twice after bone marrow transplantation. MLPA showed 12.5-Mb and 4.28-Mb regions of amplification and deletion, respectively. CONCLUSIONS: The frequency of iAMP21 is considerable in Korean pediatric patients. Our report suggests that iAMP21 in childhood B-ALL has very unfavorable impact on patient's prognosis. Additional methods such as MLPA analysis is essential to rule out patients with equivocal interphase FISH results.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfANNALS OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAsian Continental Ancestry Group/genetics*-
dc.subject.MESHB-Lymphocytes/metabolism*-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHChromosomes, Human, Pair 21*-
dc.subject.MESHCore Binding Factor Alpha 2 Subunit/genetics-
dc.subject.MESHDNA Probes/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunophenotyping-
dc.subject.MESHIn Situ Hybridization, Fluorescence-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHMale-
dc.subject.MESHMultiplex Polymerase Chain Reaction-
dc.subject.MESHPrecursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis*-
dc.subject.MESHPrecursor Cell Lymphoblastic Leukemia-Lymphoma/genetics-
dc.subject.MESHProto-Oncogene Proteins c-ets/genetics-
dc.subject.MESHRepressor Proteins/genetics-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTranslocation, Genetic-
dc.subject.MESHYoung Adult-
dc.titleFrequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorJieun Kim-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorSaeam Shin-
dc.contributor.googleauthorSeung-Tae Lee-
dc.contributor.googleauthorJong Rak Choi-
dc.identifier.doi10.3343/alm.2016.36.5.475-
dc.contributor.localIdA02524-
dc.contributor.localIdA04627-
dc.contributor.localIdA04182-
dc.contributor.localIdA04546-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.relation.journalsince2012~-
dc.identifier.pmid27374714-
dc.relation.journalbefore~2011 Korean Journal of Laboratory Medicine (대한진단검사의학회지)-
dc.subject.keywordAcute lymphoblastic leukemia-
dc.subject.keywordChildhood-
dc.subject.keywordERG-
dc.subject.keywordFISH-
dc.subject.keywordKorean-
dc.subject.keywordMLPA-
dc.subject.keywordRUNX1-
dc.subject.keywordiAMP21-
dc.contributor.alternativeNameKim, Jieun-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameLee, Seung-Tae-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorLee, Seung-Tae-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.contributor.affiliatedAuthorKim, Jieun-
dc.citation.volume36-
dc.citation.number5-
dc.citation.startPage475-
dc.citation.endPage480-
dc.identifier.bibliographicCitationANNALS OF LABORATORY MEDICINE, Vol.36(5) : 475-480, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.