Cited 6 times in
Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia
DC Field | Value | Language |
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dc.contributor.author | 김지은 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 이승태 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2017-10-26T07:45:31Z | - |
dc.date.available | 2017-10-26T07:45:31Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152479 | - |
dc.description.abstract | BACKGROUND: Intrachromosomal amplification of chromosome 21 (iAMP21) is known to be associated with poor prognosis in B-cell ALL (B-ALL). To determine the frequency and clinical characteristics of iAMP21 in Korean B-ALL patients, we performed FISH and multiplex ligation-dependent probe amplification (MLPA) analyses. METHODS: A total of 102 childhood B-ALL patients were screened with ETV6-RUNX1 FISH probes (Abbott Molecular, USA). The presence of an iAMP21 was confirmed by using MLPA P327 iAMP21-ERG probemix (MRC Holland, The Netherlands). RESULTS: iAMP21 was detected in one of the screened B-ALL patients (1/102 patients, 1.0%) who presented the ALL immunophenotype and complex karyotype at initial diagnosis. The patient relapsed twice after bone marrow transplantation. MLPA showed 12.5-Mb and 4.28-Mb regions of amplification and deletion, respectively. CONCLUSIONS: The frequency of iAMP21 is considerable in Korean pediatric patients. Our report suggests that iAMP21 in childhood B-ALL has very unfavorable impact on patient's prognosis. Additional methods such as MLPA analysis is essential to rule out patients with equivocal interphase FISH results. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | B-Lymphocytes/metabolism* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Chromosomes, Human, Pair 21* | - |
dc.subject.MESH | Core Binding Factor Alpha 2 Subunit/genetics | - |
dc.subject.MESH | DNA Probes/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Infant, Newborn | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Multiplex Polymerase Chain Reaction | - |
dc.subject.MESH | Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis* | - |
dc.subject.MESH | Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-ets/genetics | - |
dc.subject.MESH | Repressor Proteins/genetics | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Translocation, Genetic | - |
dc.subject.MESH | Young Adult | - |
dc.title | Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Jieun Kim | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Saeam Shin | - |
dc.contributor.googleauthor | Seung-Tae Lee | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.identifier.doi | 10.3343/alm.2016.36.5.475 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A04627 | - |
dc.contributor.localId | A04182 | - |
dc.contributor.localId | A04546 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.relation.journalsince | 2012~ | - |
dc.identifier.pmid | 27374714 | - |
dc.relation.journalbefore | ~2011 Korean Journal of Laboratory Medicine (대한진단검사의학회지) | - |
dc.subject.keyword | Acute lymphoblastic leukemia | - |
dc.subject.keyword | Childhood | - |
dc.subject.keyword | ERG | - |
dc.subject.keyword | FISH | - |
dc.subject.keyword | Korean | - |
dc.subject.keyword | MLPA | - |
dc.subject.keyword | RUNX1 | - |
dc.subject.keyword | iAMP21 | - |
dc.contributor.alternativeName | Kim, Jieun | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Lee, Seung-Tae | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Tae | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Kim, Jieun | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 475 | - |
dc.citation.endPage | 480 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.36(5) : 475-480, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48682 | - |
dc.type.rims | ART | - |
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