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Characteristics and Outcomes of Second Malignant Neoplasms after Childhood Cancer Treatment: Multi-Center Retrospective Survey

DC Field Value Language
dc.contributor.author유철주-
dc.contributor.author한정우-
dc.date.accessioned2017-10-26T07:45:25Z-
dc.date.available2017-10-26T07:45:25Z-
dc.date.issued2016-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152477-
dc.description.abstractThis retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5-18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33%) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45% with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18%, 33%, and 32%, respectively, whereas those with second osteosarcoma showed comparable outcomes (64%) to patients with primary counterpart and those with second thyroid carcinoma had a 100% OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAntineoplastic Agents/therapeutic use-
dc.subject.MESHCentral Nervous System Neoplasms/diagnosis-
dc.subject.MESHCentral Nervous System Neoplasms/drug therapy-
dc.subject.MESHCentral Nervous System Neoplasms/radiotherapy-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHHospitals-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHLeukemia, Myeloid, Acute/diagnosis-
dc.subject.MESHLeukemia, Myeloid, Acute/epidemiology-
dc.subject.MESHLeukemia, Myeloid, Acute/mortality-
dc.subject.MESHLeukemia, Myeloid, Acute/therapy-
dc.subject.MESHMyelodysplastic Syndromes/diagnosis-
dc.subject.MESHMyelodysplastic Syndromes/epidemiology-
dc.subject.MESHMyelodysplastic Syndromes/mortality-
dc.subject.MESHMyelodysplastic Syndromes/therapy-
dc.subject.MESHNeoplasms, Second Primary/diagnosis*-
dc.subject.MESHNeoplasms, Second Primary/epidemiology-
dc.subject.MESHNeoplasms, Second Primary/mortality-
dc.subject.MESHNeoplasms, Second Primary/therapy-
dc.subject.MESHOsteosarcoma/diagnosis-
dc.subject.MESHOsteosarcoma/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStem Cell Transplantation-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTransplantation, Autologous-
dc.subject.MESHYoung Adult-
dc.titleCharacteristics and Outcomes of Second Malignant Neoplasms after Childhood Cancer Treatment: Multi-Center Retrospective Survey-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorKyung-Nam Koh-
dc.contributor.googleauthorKeon Hee Yoo-
dc.contributor.googleauthorHo Joon Im-
dc.contributor.googleauthorKi Woong Sung-
dc.contributor.googleauthorHong Hoe Koo-
dc.contributor.googleauthorHyo Sun Kim-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorJong Hyung Yoon-
dc.contributor.googleauthorHyeon Jin Park-
dc.contributor.googleauthorByung-Kiu Park-
dc.contributor.googleauthorHee Jo Baek-
dc.contributor.googleauthorHoon Kook-
dc.contributor.googleauthorJun Ah Lee-
dc.contributor.googleauthorJae Min Lee-
dc.contributor.googleauthorKwang Chul Lee-
dc.contributor.googleauthorSoon Ki Kim-
dc.contributor.googleauthorMeerim Park-
dc.contributor.googleauthorYoung-Ho Lee-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorJong Jin Seo-
dc.identifier.doi10.3346/jkms.2016.31.8.1254-
dc.contributor.localIdA04325-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid27478336-
dc.subject.keywordCancer-
dc.subject.keywordChildhood-
dc.subject.keywordSecond Neoplasm-
dc.subject.keywordSurvivors-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.citation.volume31-
dc.citation.number8-
dc.citation.startPage1254-
dc.citation.endPage1261-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.31(8) : 1254-1261, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48680-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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