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Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma

DC Field Value Language
dc.contributor.author고윤우-
dc.contributor.author김주항-
dc.contributor.author김혜련-
dc.contributor.author이창걸-
dc.contributor.author조병철-
dc.contributor.author최은창-
dc.date.accessioned2017-10-26T07:45:09Z-
dc.date.available2017-10-26T07:45:09Z-
dc.date.issued2016-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152473-
dc.description.abstractBACKGROUND: The purpose of this study was to assess the efficacy and safety of induction chemotherapy with docetaxel-S-1, and radiotherapy (RT) with concurrent daily cisplatin in locally advanced head and neck carcinoma. METHOD: Fifty patients received 2 cycles of induction chemotherapy with induction chemotherapy with docetaxel and S-1, followed by 7 cycles of RT with concurrent daily cisplatin. RESULTS: The most frequent grade 3 to 4 hematologic toxicity was neutropenia (14%). Forty of 50 patients who completed induction chemotherapy with docetaxel and S-1 subsequently started RT with concurrent daily cisplatin, all within 3 to 4 weeks after the start of the second cycle of induction chemotherapy with docetaxel and S-1. The best response to induction chemotherapy with docetaxel and S-1 and after completion of RT with concurrent daily cisplatin was partial response (PR) in 52.5% and complete response in 47.5%, respectively. With a median follow-up of 61 months, 5-year progression-free survival (PFS) and overall survival (OS) were 63.3% and 65.7%, respectively. CONCLUSION: Administration of induction chemotherapy with docetaxel and S-1 before RT with concurrent daily cisplatin chemoradiotherapy (CRT) resulted in a high response rate with good tolerability, and did not compromise subsequent CRT.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley And Sons-
dc.relation.isPartOfHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntimetabolites, Antineoplastic/administration & dosage-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHCarcinoma, Squamous Cell-
dc.subject.MESHChemoradiotherapy*-
dc.subject.MESHCisplatin/administration & dosage*-
dc.subject.MESHDrug Combinations-
dc.subject.MESHFemale-
dc.subject.MESHFluorouracil-
dc.subject.MESHHead and Neck Neoplasms/therapy*-
dc.subject.MESHHumans-
dc.subject.MESHInduction Chemotherapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOxonic Acid/administration & dosage*-
dc.subject.MESHTaxoids/administration & dosage*-
dc.subject.MESHTegafur/administration & dosage*-
dc.subject.MESHYoung Adult-
dc.titleInduction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorEun Chang Choi-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorYoon Woo Koh-
dc.contributor.googleauthorByoung Chul Cho-
dc.identifier.doi10.1002/hed.24294-
dc.contributor.localIdA00945-
dc.contributor.localIdA01166-
dc.contributor.localIdA03240-
dc.contributor.localIdA03822-
dc.contributor.localIdA04161-
dc.contributor.localIdA00133-
dc.relation.journalcodeJ00963-
dc.identifier.eissn1097-0347-
dc.identifier.pmid26890965-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/hed.24294/abstract-
dc.subject.keywordS-1-
dc.subject.keyworddocetaxel-
dc.subject.keywordhead and neck-
dc.subject.keywordinduction chemotherapy-
dc.subject.keywordsquamous cell carcinoma-
dc.contributor.alternativeNameKho, Yoon Woo-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameChoi, Eun Chang-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorChoi, Eun Chang-
dc.contributor.affiliatedAuthorKho, Yoon Woo-
dc.citation.volume38-
dc.citation.numberSuppl. 1-
dc.citation.startPage1653-
dc.citation.endPage1659-
dc.identifier.bibliographicCitationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.38(Suppl. 1) : 1653-1659, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48676-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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