0 102

Cited 12 times in

Malnutrition Identified by the Nutritional Risk Index and Poor Prognosis in Advanced Epithelial Ovarian Carcinoma

 Ga Won Yim  ;  Kyung Jin Eoh  ;  Sang Wun Kim  ;  Eun Ji Nam  ;  Young Tae Kim 
 Nutrition and Cancer- an International Journal, Vol.68(5) : 772-779, 2016 
Journal Title
 Nutrition and Cancer- an International Journal 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Body Weight ; Diet ; Female ; Follow-Up Studies ; Humans ; Malnutrition/diagnosis* ; Malnutrition/mortality* ; Middle Aged ; Neoplasms, Glandular and Epithelial/complications* ; Neoplasms, Glandular and Epithelial/mortality ; Nutrition Assessment ; Nutritional Status ; Ovarian Neoplasms/complications* ; Ovarian Neoplasms/mortality ; Prevalence ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Young Adult
Ovarian cancer is a chronic disease with a risk of malnutrition. Nutritional Risk Index (NRI) has been reported as a simple and accurate tool to assess the nutritional status. We sought to explore the prevalence of malnutrition and its association with survival in ovarian cancer. A retrospective study was conducted in 213 advanced ovarian cancer patients. NRI was calculated before and at the end of treatment using patients' body weight and serum albumin level. Overall survival (OS) and progression-free survival (PFS) were estimated by Kaplan-Meier method, and associations were assessed using a Cox proportional hazards analysis adjusted for known prognostic variables. Moderate to severely malnourished patients had lower 5-yr OS (45.3%) compared to normal to mild group (64.0%), respectively (P?=?0.024). Adjusted for covariates, the relative risk of death was 5.8 times higher in moderate/severely malnourished group identified at the last course of chemotherapy (HR?=?5.896, 95% CI?=?2.723-12.764, P?<?0.001). Similarly, this cohort had shorter PFS compared with normal to mild risk group (median 15 vs. 28 months, P?=?0.011). Malnutrition is prevalent among ovarian cancer patients and is found to be a significant predictor for mortality.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
김상운(Kim, Sang Wun) ORCID logo https://orcid.org/0000-0002-8342-8701
김영태(Kim, Young Tae) ORCID logo https://orcid.org/0000-0002-7347-1052
남은지(Nam, Eun Ji)
어경진(Eoh, Kyung Jin) ORCID logo https://orcid.org/0000-0002-1684-2267
임가원(Yim, Ga Won)
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.