Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Body Weight ; Diet ; Female ; Follow-Up Studies ; Humans ; Malnutrition/diagnosis* ; Malnutrition/mortality* ; Middle Aged ; Neoplasms, Glandular and Epithelial/complications* ; Neoplasms, Glandular and Epithelial/mortality ; Nutrition Assessment ; Nutritional Status ; Ovarian Neoplasms/complications* ; Ovarian Neoplasms/mortality ; Prevalence ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Young Adult
Abstract
Ovarian cancer is a chronic disease with a risk of malnutrition. Nutritional Risk Index (NRI) has been reported as a simple and accurate tool to assess the nutritional status. We sought to explore the prevalence of malnutrition and its association with survival in ovarian cancer. A retrospective study was conducted in 213 advanced ovarian cancer patients. NRI was calculated before and at the end of treatment using patients' body weight and serum albumin level. Overall survival (OS) and progression-free survival (PFS) were estimated by Kaplan-Meier method, and associations were assessed using a Cox proportional hazards analysis adjusted for known prognostic variables. Moderate to severely malnourished patients had lower 5-yr OS (45.3%) compared to normal to mild group (64.0%), respectively (P?=?0.024). Adjusted for covariates, the relative risk of death was 5.8 times higher in moderate/severely malnourished group identified at the last course of chemotherapy (HR?=?5.896, 95% CI?=?2.723-12.764, P?