Cited 131 times in
Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02)
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.date.accessioned | 2017-10-26T07:44:47Z | - |
dc.date.available | 2017-10-26T07:44:47Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152462 | - |
dc.description.abstract | We hypothesized that plasma-based EGFR mutation analysis for NSCLC may be feasible for monitoring treatment response to EGFR TKIs and also predict drug resistance.Clinically relevant mutations including exon 19 deletion (ex19del), L858R and T790M were analyzed using droplet digital PCR (ddPCR) in longitudinally collected plasma samples (n = 367) from 81 NSCLC patients treated with EGFR TKI. Of a total 58 baseline cell-free DNA (cfDNA) samples available for ddPCR analysis, 43 (74.1%) had the same mutation in the matched tumors (clinical sensitivity: 70.8% [17/24] for L858R and 76.5% [26/34] for ex19del). The concordance rates of plasma with tissue-based results of EGFR mutations were 87.9% for L858R and 86.2% for ex19del. All 40 patients who were detected EGFR mutations at baseline showed a dramatic decrease of mutant copies (>50%) in plasma during the first two months after treatment. Median progression-free survival (PFS) was 10.1 months for patients with undetectable EGFR v 6.3 months for detectable EGFR mutations in blood after two-month treatment (HR 3.88, 95% CI 1.48-10.19, P = 0.006). We observed emerging resistance with early detection of T790M as a secondary mutation in 14 (28.6%) of 49 patients. Plasma-based EGFR mutation analysis using ddPCR can monitor treatment response to EGFR TKIs and can lead to early detection of EGFR TKIs resistance. Further studies confirming clinical implications of EGFR mutation in plasma are warranted to guide optimal therapeutic strategies upon knowledge of treatment response and resistance. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/blood | - |
dc.subject.MESH | Adenocarcinoma/drug therapy | - |
dc.subject.MESH | Adenocarcinoma/genetics | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor/blood | - |
dc.subject.MESH | Biomarkers, Tumor/genetics* | - |
dc.subject.MESH | Carcinoma, Adenosquamous/blood | - |
dc.subject.MESH | Carcinoma, Adenosquamous/drug therapy | - |
dc.subject.MESH | Carcinoma, Adenosquamous/genetics | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/blood* | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/drug therapy | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/genetics* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/blood | - |
dc.subject.MESH | Carcinoma, Squamous Cell/drug therapy | - |
dc.subject.MESH | Carcinoma, Squamous Cell/genetics | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | Drug Resistance, Neoplasm/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gene Expression Profiling* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Lung Neoplasms/blood | - |
dc.subject.MESH | Lung Neoplasms/drug therapy | - |
dc.subject.MESH | Lung Neoplasms/genetics | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation/genetics* | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Protein Kinase Inhibitors/therapeutic use* | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/blood | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/genetics* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02) | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Ji Yun Lee | - |
dc.contributor.googleauthor | Xu Qing | - |
dc.contributor.googleauthor | Wei Xiumin | - |
dc.contributor.googleauthor | Bai Yali | - |
dc.contributor.googleauthor | Sangah Chi | - |
dc.contributor.googleauthor | So Hyeon Bak | - |
dc.contributor.googleauthor | Ho Yun Lee | - |
dc.contributor.googleauthor | Jong-Mu Sun | - |
dc.contributor.googleauthor | Se-Hoon Lee | - |
dc.contributor.googleauthor | Jin Seok Ahn | - |
dc.contributor.googleauthor | Eun Kyung Cho | - |
dc.contributor.googleauthor | Dong-Wan Kim | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.contributor.googleauthor | Young Joo Min | - |
dc.contributor.googleauthor | Sin-Ho Jung | - |
dc.contributor.googleauthor | Keunchil Park | - |
dc.contributor.googleauthor | Mao Mao | - |
dc.contributor.googleauthor | Myung-Ju Ahn | - |
dc.identifier.doi | 10.18632/oncotarget.6874 | - |
dc.contributor.localId | A01166 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 26755650 | - |
dc.subject.keyword | EGFR | - |
dc.subject.keyword | NSCLC | - |
dc.subject.keyword | TKI treatment | - |
dc.subject.keyword | droplet digital PCR | - |
dc.subject.keyword | liquid biopsy | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | Kim, Hye Ryun | - |
dc.citation.volume | 7 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 6984 | - |
dc.citation.endPage | 6993 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.7(6) : 6984-6993, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48665 | - |
dc.type.rims | ART | - |
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