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The Role of Neoadjuvant Chemotherapy in the Treatment of Nasopharyngeal Carcinoma: A Multi-institutional Retrospective Study (KROG 11-06) Using Propensity Score Matching Analysis

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dc.contributor.author금기창-
dc.contributor.author이창걸-
dc.contributor.author차지혜-
dc.date.accessioned2017-10-26T07:44:06Z-
dc.date.available2017-10-26T07:44:06Z-
dc.date.issued2016-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152444-
dc.description.abstractPURPOSE: We compared the treatment results and toxicity in nasopharyngeal carcinoma (NPC) patients treated with concurrent chemotherapy (CCRT) alone (the CRT arm) or neoadjuvant chemotherapy followed by CCRT (the NCT arm). MATERIALS AND METHODS: A multi-institutional retrospective study was conducted to review NPC patterns of care and treatment outcome. Data of 568 NPC patients treated by CCRT alone or by neoadjuvant chemotherapy followed by CCRT were collected from 15 institutions. Patients in both treatment arms were matched using the propensity score matching method, and the clinical outcomes were analyzed. RESULTS: After matching, 300 patients (150 patients in each group) were selected for analysis. Higher 5-year locoregional failure-free survival was observed in the CRT arm (85% vs. 72%, p=0.014). No significant differences in distant failure-free survival (DFFS), disease-free survival (DFS), and overall survival were observed between groups. In subgroup analysis, the NCT arm showed superior DFFS and DFS in stage IV patients younger than 60 years. No significant difference in compliance and toxicity was observed between groups, except the radiation therapy duration was slightly shorter in the CRT arm (50.0 days vs. 53.9 days, p=0.018). CONCLUSION: This study did not show the superiority of NCT followed by CCRT over CCRT alone. Because NCT could increase the risk of locoregional recurrences, it can only be considered in selected young patients with advanced stage IV disease. The role of NCT remains to be defined and should not be viewed as the standard of care.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/adverse effects-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use*-
dc.subject.MESHCarcinoma/mortality-
dc.subject.MESHCarcinoma/pathology-
dc.subject.MESHCarcinoma/therapy*-
dc.subject.MESHChemoradiotherapy/adverse effects-
dc.subject.MESHChemoradiotherapy/methods*-
dc.subject.MESHChemoradiotherapy/statistics & numerical data-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNasopharyngeal Neoplasms/mortality-
dc.subject.MESHNasopharyngeal Neoplasms/pathology-
dc.subject.MESHNasopharyngeal Neoplasms/therapy*-
dc.subject.MESHNeoadjuvant Therapy/adverse effects-
dc.subject.MESHNeoadjuvant Therapy/methods*-
dc.subject.MESHNeoadjuvant Therapy/statistics & numerical data-
dc.subject.MESHNeoplasm Recurrence, Local/mortality-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Recurrence, Local/therapy*-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPatient Compliance/statistics & numerical data-
dc.subject.MESHPatient Selection-
dc.subject.MESHPropensity Score-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleThe Role of Neoadjuvant Chemotherapy in the Treatment of Nasopharyngeal Carcinoma: A Multi-institutional Retrospective Study (KROG 11-06) Using Propensity Score Matching Analysis-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorJin Ho Song-
dc.contributor.googleauthorHong-Gyun Wu-
dc.contributor.googleauthorBhum Suk Keam-
dc.contributor.googleauthorJeong Hun Hah-
dc.contributor.googleauthorYong Chan Ahn-
dc.contributor.googleauthorDongryul Oh-
dc.contributor.googleauthorJae Myoung Noh-
dc.contributor.googleauthorHyo Jung Park-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorKwan Ho Cho-
dc.contributor.googleauthorSung Ho Moon-
dc.contributor.googleauthorJi-Yoon Kim-
dc.contributor.googleauthorWoong-Ki Chung-
dc.contributor.googleauthorYoung Taek Oh-
dc.contributor.googleauthorWon Taek Kim-
dc.contributor.googleauthorMoon-June Cho-
dc.contributor.googleauthorChul Seung Kay-
dc.contributor.googleauthorYeon-Sil Kim-
dc.identifier.doi10.4143/crt.2015.265-
dc.contributor.localIdA03240-
dc.contributor.localIdA05047-
dc.contributor.localIdA00272-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.relation.journalsince2001~-
dc.identifier.pmid26727716-
dc.relation.journalbefore~2001 Journal of the Korean Cancer Research Association (대한암학회지)-
dc.subject.keywordChemoradiotherapy-
dc.subject.keywordInduction chemotherapy-
dc.subject.keywordNasopharyngeal neoplasms-
dc.subject.keywordRadiotherapy-
dc.subject.keywordRepublic of Korea-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameCha, Ji Hye-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorCha, Ji Hye-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.citation.volume48-
dc.citation.number3-
dc.citation.startPage917-
dc.citation.endPage927-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.48(3) : 917-927, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48649-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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