Cited 13 times in
Attainment of low-density lipoprotein cholesterol goal after endovascular treatment is associated with reduced cardiovascular events in patients with peripheral arterial disease
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍명기 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 신동호 | - |
dc.date.accessioned | 2017-10-26T07:42:36Z | - |
dc.date.available | 2017-10-26T07:42:36Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0741-5214 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152408 | - |
dc.description.abstract | OBJECTIVE: The relationship between attainment of low-density lipoprotein cholesterol (LDL-C) levels and clinical outcomes in patients with peripheral arterial disease (PAD) has received little attention. We sought to investigate clinical outcomes in relation to attainment of LDL-C goals in patients with PAD after endovascular treatment. METHODS: We reviewed 342 PAD patients treated with endovascular therapy from 2010 through 2012. We categorized patients into two groups based on the attained LDL-C levels at short-term follow-up (mean, 4.8 ± 2.8 months): group A (n = 160), with LDL-C <70 mg/dL; and group B (n = 182), with LDL-C ≥70 mg/dL. The primary end point was major adverse cardiovascular events (MACEs), a composite of all-cause death, nonfatal myocardial infarction, and stroke. RESULTS: Baseline characteristics were similar between group A and group B except for obstructive pulmonary disease (0% vs 7%; P = .001). More patients in group A received statin therapy than those in group B (93% vs 76%; P < .001). MACEs (4% vs 10%; P = .002) and all-cause mortality (2% vs 7%; P = .007) occurred less frequently in group A than in group B at 2 years. A Cox proportional hazards multivariate regression model identified attainment of LDL-C goal <70 mg/dL at short-term follow-up as an independent predictor of reduced MACEs (hazard ratio, 0.25; 95% confidence interval, 0.09-0.67; P = .006) along with age as a predictor of increased MACEs (hazard ratio, 1.04; 95% confidence interval, 1.00-1.08; P = .031). CONCLUSIONS: Attainment of LDL-C goal <70 mg/dL at short-term follow-up is an independent predictor of reduced mortality and cardiovascular events after endovascular therapy in patients with PAD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF VASCULAR SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Cardiovascular Diseases/etiology | - |
dc.subject.MESH | Cardiovascular Diseases/mortality | - |
dc.subject.MESH | Cardiovascular Diseases/prevention & control* | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Cholesterol, LDL/blood* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Dyslipidemias/blood | - |
dc.subject.MESH | Dyslipidemias/complications | - |
dc.subject.MESH | Dyslipidemias/diagnosis | - |
dc.subject.MESH | Dyslipidemias/drug therapy* | - |
dc.subject.MESH | Endovascular Procedures*/adverse effects | - |
dc.subject.MESH | Endovascular Procedures*/mortality | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use* | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Peripheral Arterial Disease/complications | - |
dc.subject.MESH | Peripheral Arterial Disease/diagnosis | - |
dc.subject.MESH | Peripheral Arterial Disease/mortality | - |
dc.subject.MESH | Peripheral Arterial Disease/therapy* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Attainment of low-density lipoprotein cholesterol goal after endovascular treatment is associated with reduced cardiovascular events in patients with peripheral arterial disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jung-Hee Lee | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Dong-Ho Shin | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 10.1016/j.jvs.2015.09.059 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A00127 | - |
dc.relation.journalcode | J01924 | - |
dc.identifier.eissn | 1097-6809 | - |
dc.identifier.pmid | 26603545 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0741521415020200?via%3Dihub | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.citation.volume | 63 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 756 | - |
dc.citation.endPage | 763 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VASCULAR SURGERY, Vol.63(3) : 756-763, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48615 | - |
dc.type.rims | ART | - |
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