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Surgical management of extra-regional lymph node metastasis in colorectal cancer

Authors
 Mahdi H. Albandar  ;  Min Soo Cho  ;  Sung Uk Bae  ;  Nam Kyu Kim 
Citation
 EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, Vol.16(5) : 503-513, 2016 
Journal Title
 EXPERT REVIEW OF ANTI-INFECTIVE THERAPY 
ISSN
 1478-7210 
Issue Date
2016
MeSH
Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery* ; Colorectal Neoplasms/therapy ; Humans ; Lymph Node Excision/methods* ; Lymphatic Metastasis ; Neoplasm Recurrence, Local ; Prognosis ; Survival Rate
Keywords
Extra-regional ; colorectal cancer ; lymph node ; surgical management and metastasis
Abstract
One of the major problems in rectal cancer surgery is local recurrence, found in an average of 21% to 46% cases in 1990. However, the advent of chemo-radiotherapy (CRT) and total mesorectal excision (TME) improve local control and enhances survival rates in colorectal cancer (CRC). Regional lymph node involvement is determined to be an independent prognostic factor in local recurrence; however, extra-regional lymph node (ERLN) metastasis has a higher recurrence rate (up to 58.1%). Lack of supportive data in management of ERLN metastasis in CRC has added further strain and challenges to structure a unique treatment strategy. ERLN refers to extra-mesenteric involvement either in the para-aortic lymph node (PALN) or the lateral pelvic lymph node (LPLN). Treatment of ERLN metastasis is challenging because of the shortage of the resources. Here, we will outline and summarize approaches and management of ERLN metastasis. We also aim to clarify the role of surgical intervention in CRC.
Full Text
http://www.tandfonline.com/doi/abstract/10.1586/14737140.2016.1162718
DOI
10.1586/14737140.2016.1162718
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Cho, Min Soo(조민수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152402
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