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Radiation Pneumonitis in Association with Internal Mammary Node Irradiation in Breast Cancer Patients: An Ancillary Result from the KROG 08-06 Study

DC FieldValueLanguage
dc.contributor.author김용배-
dc.contributor.author서창옥-
dc.contributor.author최진현-
dc.date.accessioned2017-10-26T07:41:10Z-
dc.date.available2017-10-26T07:41:10Z-
dc.date.issued2016-
dc.identifier.issn1738-6756-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152383-
dc.description.abstractPurpose : The aim of this study is to present the incidence of radiation pneumonitis (RP) reported within 6 months after treatment for breast cancer with or without internal mammary node irradiation (IMNI). Methods : In the Korean Radiation Oncology Group (KROG) 08-06 phase III randomized trial, patients who were node-positive after surgery were randomly assigned to receive radiotherapy either with or without IMNI. A total of 747 patients were enrolled, and three-dimensional treatment planning with computed tomography simulation was performed for all patients. Of the 747 patients, 722 underwent chest X-rays before and within 6 months after radiotherapy. These 722 patients underwent evaluation, and RP was diagnosed on the basis of chest radiography findings and clinical symptoms. The relationship between the incidence of RP and clinical/dosimetric parameters was analyzed. Results : RP developed in 35 patients (4.8%), including grade 1 RP in 26 patients (3.6%), grade 2 RP in nine patients (1.2%); there was no incidence of grade 3 or higher RP. Grade 2 RP cases were observed in only the IMNI group. The risk of developing RP was influenced by IMNI treatment; pneumonitis occurred in 6.5% of patients (n=23/356) who underwent IMNI and in 3.3% of patients (n=12/366) who did not (p=0.047). The differences in lung dosimetric parameters (mean lung dose, V10?40) were statistically significant between the two groups. Conclusion : IMNI treatment resulted in increased radiation exposure to the lung and a higher rate of RP, but the incidence and severity of RP was minimal and acceptable. This minor impact on morbidity should be balanced with the impact on survival outcome in future analyses.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean, English-
dc.publisherKorean Breast Cancer Society-
dc.relation.isPartOfJOURNAL OF BREAST CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRadiation Pneumonitis in Association with Internal Mammary Node Irradiation in Breast Cancer Patients: An Ancillary Result from the KROG 08-06 Study-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorJinhyun Choi-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorKyung Hwan Shin-
dc.contributor.googleauthorSung-Ja Ahn-
dc.contributor.googleauthorHyung-Sik Lee-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorSu Ssan Kim-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorKyu Chan Lee-
dc.contributor.googleauthorDong Won Kim-
dc.contributor.googleauthorHyun Suk Suh-
dc.contributor.googleauthorKyung Ran Park-
dc.contributor.googleauthorHyun Soo Shin-
dc.contributor.googleauthorChang-Ok Suh-
dc.identifier.doi10.4048/jbc.2016.19.3.275-
dc.contributor.localIdA01919-
dc.contributor.localIdA04697-
dc.contributor.localIdA00744-
dc.relation.journalcodeJ01279-
dc.identifier.eissn2092-9900-
dc.relation.journalsince2005~-
dc.identifier.pmid27721877-
dc.relation.journalbefore~2004 Journal of Korean Breast Cancer Society (한국유방암학회지)-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordLymphatic irradiation-
dc.subject.keywordRadiation pneumonitis-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameChoi, Jinhyun-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorChoi, Jinhyun-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.citation.volume19-
dc.citation.number3-
dc.citation.startPage275-
dc.citation.endPage282-
dc.identifier.bibliographicCitationJOURNAL OF BREAST CANCER, Vol.19(3) : 275-282, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48113-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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