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Biomarker-specific conjugated nanopolyplexes for the active coloring of stem-like cancer cells

Authors
 Yoochan Hong  ;  Eugene Lee  ;  Jihye Choi  ;  Seungjoo Haam  ;  Jin-Suck Suh  ;  Jaemoon Yang 
Citation
 NANOTECHNOLOGY, Vol.27(22) : 225101, 2016 
Journal Title
 NANOTECHNOLOGY 
ISSN
 0957-4484 
Issue Date
2016
Keywords
polyaniline ; hyaluronic acid ; cancer ; colorimetric probes ; redox environment
Abstract
Stem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. For the most sensitive recognition of the cellular redox at a single nanoparticle scale, a nano-scattering spectrum imaging analyzer system was introduced. The conjugated polyplexes showed a specific targeting ability toward CD44-expressing cancer cells as well as a dramatic change in its color, which depended on the redox potential in the light-scattered images. Therefore, these polyaniline-based conjugated polyplexes as well as analytical processes that include light-scattering imaging and measurements of scattering spectra, clearly establish a systematic method for the detection and monitoring of cancer microenvironments.
Full Text
http://iopscience.iop.org/article/10.1088/0957-4484/27/22/225101/meta
DOI
10.1088/0957-4484/27/22/225101
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152361
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