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Lethal Hyperammonemia due to Ornithine Transcarbamylase Deficiency in a Patient with Severe Septic Shock
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 김송이 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김은영 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 송주한 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정경수 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2017-10-26T07:40:00Z | - |
dc.date.available | 2017-10-26T07:40:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2383-4870 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152351 | - |
dc.description.abstract | Severe hyperammonemia can occur as a result of inherited or acquired liver enzyme defects in the urea cycle, among which ornithine transcarbamylase deficiency (OTCD) is the most common form. We report a very rare case of a 45-year-old Korean male who was admitted to the intensive care unit (ICU) due to severe septic shock with acute respiratory failure caused by Pneumocystis jiroveci pneumonia. During his ICU stay with ventilator care, the patient suffered from marked hyperammonemia (>1,700 μg/dL) with abrupt mental change leading to life-threatening cerebral edema. Despite every effort including continuous renal replacement therapy and use of a molecular adsorbent recirculating system (extracorporeal liver support?albumin dialysis) to lower his serum ammonia level, the patient was not recovered. The lethal hyperammonemia in the patient was later proven to be a manifestation of acquired liver enzyme defect known as OTCD, which is triggered by serious catabolic conditions, such as severe septic shock with acute respiratory failure. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Critical Care Medicine | - |
dc.relation.isPartOf | Korean Journal of Critical Care Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Lethal Hyperammonemia due to Ornithine Transcarbamylase Deficiency in a Patient with Severe Septic Shock | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Ji An Hwang | - |
dc.contributor.googleauthor | Joo Han Song | - |
dc.contributor.googleauthor | Young Seok Lee | - |
dc.contributor.googleauthor | Kyung Soo Chung | - |
dc.contributor.googleauthor | Song Yee Kim | - |
dc.contributor.googleauthor | Eun Young Kim | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.identifier.doi | 10.4266/kjccm.2016.31.2.140 | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A00811 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A02062 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03570 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A00057 | - |
dc.relation.journalcode | J01995 | - |
dc.relation.journalsince | 2004~ | - |
dc.relation.journalbefore | ~2003 Korean Journal of Critical Care Medicine (대한중환자의학회지) | - |
dc.subject.keyword | cerebral edema | - |
dc.subject.keyword | hyperammonemia | - |
dc.subject.keyword | ornithine transcarbamylase deficiency | - |
dc.subject.keyword | respiratory failure | - |
dc.subject.keyword | septic shock. | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Song Yi | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Kim, Eun Young | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Song, Joo Han | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Kyung Soo | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kim, Song Yi | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Song, Joo Han | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 140 | - |
dc.citation.endPage | 145 | - |
dc.identifier.bibliographicCitation | Korean Journal of Critical Care Medicine, Vol.31(2) : 140-145, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48086 | - |
dc.type.rims | ART | - |
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