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The Implications of Endoscopic Ulcer in Early Gastric Cancer: Can We Predict Clinical Behaviors from Endoscopy?

DC Field Value Language
dc.contributor.author김종원-
dc.contributor.author최승호-
dc.contributor.author김지현-
dc.contributor.author노성훈-
dc.contributor.author박재준-
dc.contributor.author박효진-
dc.contributor.author윤영훈-
dc.date.accessioned2017-10-26T07:39:55Z-
dc.date.available2017-10-26T07:39:55Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152350-
dc.description.abstractBACKGROUND: The presence of ulcer in early gastric cancer (EGC) is important for the feasibility of endoscopic resection, only a few studies have examined the clinicopathological implications of endoscopic ulcer in EGC. OBJECTIVES: To determine the role of endoscopic ulcer as a predictor of clinical behaviors in EGC. METHODS: Data of 3,270 patients with EGC who underwent surgery between January 2005 and December 2012 were reviewed. Clinicopathological characteristics were analyzed in relation to the presence and stage of ulcer in EGC. Based on endoscopic findings, the stage of ulcer was categorized as active, healing, or scar. Logistic regression analysis was performed to analyze factors associated with lymph node metastasis (LNM). RESULTS: 2,343 (71.7%) patients had endoscopic findings of ulceration in EGC. Submucosal (SM) invasion, LNM, lymphovascular invasion (LVI), perineural invasion, and undifferentiated-type histology were significantly higher in ulcerative than non-ulcerative EGC. Comparison across different stages of ulcer revealed that SM invasion, LNM, and LVI were significantly associated with the active stage, and that these features exhibited significant stage-based differences, being most common at the active stage, and least common at the scar stage. The presence of endoscopic ulcer and active status of the ulcer were identified as independent risk factors for LNM. CONCLUSIONS: Ulcerative EGC detected by endoscopy exhibited more aggressive behaviors than non-ulcerative EGC. Additionally, the endoscopic stage of ulcer may predict the clinicopathological behaviors of EGC. Therefore, the appearance of ulcers should be carefully evaluated to determine an adequate treatment strategy for EGC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHEarly Detection of Cancer-
dc.subject.MESHFemale-
dc.subject.MESHGastrectomy-
dc.subject.MESHGastric Mucosa/pathology-
dc.subject.MESHGastroscopy-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHStomach Neoplasms/diagnosis-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHStomach Neoplasms/surgery-
dc.subject.MESHUlcer/pathology*-
dc.titleThe Implications of Endoscopic Ulcer in Early Gastric Cancer: Can We Predict Clinical Behaviors from Endoscopy?-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorYoo Jin Lee-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorSung Hoon Noh-
dc.identifier.doi10.1371/journal.pone.0164339-
dc.contributor.localIdA04102-
dc.contributor.localIdA00996-
dc.contributor.localIdA01281-
dc.contributor.localIdA01636-
dc.contributor.localIdA01774-
dc.contributor.localIdA02583-
dc.contributor.localIdA00925-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27741275-
dc.contributor.alternativeNameKim, Jong Won-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameYoun, Young Hoon-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorYoun, Young Hoon-
dc.contributor.affiliatedAuthorKim, Jong Won-
dc.citation.volume11-
dc.citation.number10-
dc.citation.startPagee0164339-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(10) : e0164339, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48085-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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