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PET/CT Response Criteria (European Organization for Research and Treatment of Cancer) Predict Survival Better Than Response Evaluation Criteria in Solid Tumors in Locally Advanced Cervical Cancer Treated With Chemoradiation

Authors
 Yoon, Jung Won  ;  Kim, Sunghoon  ;  Kim, Sang Wun  ;  Kim, Young Tae  ;  Kang, Won Jun  ;  Nam, Eun Ji 
Citation
 Clinical Nuclear Medicine, Vol.41(9) : 677-682, 2016 
Journal Title
 Clinical Nuclear Medicine 
ISSN
 0363-9762 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Chemoradiotherapy*/methods ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18/metabolism ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Multimodal Imaging ; Positron Emission Tomography Computed Tomography*/methods ; Predictive Value of Tests ; Prognosis ; Radiopharmaceuticals/metabolism ; Regression Analysis ; Response Evaluation Criteria in Solid Tumors ; Uterine Cervical Neoplasms/diagnostic imaging* ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/therapy*
Abstract
PURPOSE: To investigate whether the ratio of SUVs measured with F-FDG PET/CT between pretreatment and posttreatment has prognostic value in patients with locally advanced cervical cancer treated with primary chemoradiation therapy. METHODS: Cases of locally advanced cervical cancer (International Federation of Gynecology and Obstetrics stages IB1 to IVA) treated with a nonsurgical curative modality (172 cases including chemoradiation or radiation therapy) were reviewed. F-FDG PET/CT parameters, including SUVmax and SUVmean, were evaluated by F-FDG PET/CT performed prior to treatment and 6 weeks after the end of treatment. Metabolic response was evaluated according to the European Organization for Research and Treatment of Cancer guidelines and was compared with radiologic response measured according to the Response Evaluation Criteria In Solid Tumours (RECIST). RESULTS: In total, 142 patients receiving chemoradiation showed radiologic responses (median 56% decrease in maximal diameter), whereas 160 and 146 patients showed metabolic responses measured with SUVmax and SUVmean, respectively (73% decrease in SUVmax; 48% decrease in SUVmean). Radiologic response and metabolic response were significantly correlated for SUVmax and SUVmean (P = 0.0009; P = 0.0457, respectively). Kaplan-Meier analysis revealed significant differences in overall survival and progression-free survival between the responder and nonresponder groups, based on the European Organization for Research and Treatment of Cancer criteria (both P < 0.001), whereas no significant difference was found when using RECIST criteria (P = 0.058, P = 0.088, respectively). CONCLUSIONS: F-FDG PET/CT parameters are good prognostic markers for the response of cervical cancer patients to concurrent chemoradiation therapy, as compared with the RECIST criteria.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003072-201609000-00001&LSLINK=80&D=ovft
DOI
10.1097/RLU.0000000000001269
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
강원준(Kang, Won Jun) ORCID logo https://orcid.org/0000-0002-2107-8160
김상운(Kim, Sang Wun) ORCID logo https://orcid.org/0000-0002-8342-8701
김성훈(Kim, Sung Hoon) ORCID logo https://orcid.org/0000-0002-1645-7473
김영태(Kim, Young Tae) ORCID logo https://orcid.org/0000-0002-7347-1052
남은지(Nam, Eun Ji)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152315
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