Cited 28 times in
CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-γ? Th1 Cells or Foxp3? Regulatory T Cells in the Lung
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.contributor.author | 이재현 | - |
dc.date.accessioned | 2017-10-26T07:38:24Z | - |
dc.date.available | 2017-10-26T07:38:24Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152312 | - |
dc.description.abstract | PURPOSE: CpG oligodeoxynucleotide (CpG-ODN), a TLR9 agonist, activates innate immunity and induces Th1 response. Although the immune modulatory effect of CpG-ODN has been extensively studied, its function in cockroach extract-induced allergic asthma has not been studied. Here, we investigated the inhibitory function of CpG-ODN in cockroach extract-induced asthma in mice with different treatment schemes. METHODS: Scheme 1: BALB/C mice were intra-nasally co-administered by cockroach extract and CpG-ODN twice a week for 3 weeks; Scheme 2: The mice were intra-nasally pre-treated with CpG-ODN at day 0 and cockroach allergen challenge was performed from day 3 as in scheme 1. Scheme 3: Cockroach allergen challenge was performed as in scheme 1 and CpG-ODN was post-treated at day 21. Then, BAL cell count, flow cytometric analysis of alveolar macrophages, regulatory T cells, and lung tissue histology, Th1 and Th2 cytokines, serum IgE, cockroach specific IgE, IgG1/IgG2a ratio, and airway hyper-responsiveness were evaluated. RESULTS: Mice with repeated intra-nasal exposure to CpG-ODN showed a dramatic decrease in eosinophilic inflammation, goblet cell hyperplasia, and airway hyper-responsiveness with reduction of IL-13, IL-5, and serum IgE, cockroach specific IgE and IgG1/IgG2a ratio. This inhibitory function might be related to the up-regulation of IL-10 and CD4?Foxp3? regulatory T cells in the lung. Interestingly, one-time challenge of CpG-ODN either prior or posterior to cockroach extract exposure could modulate airway inflammation and hyper-responsiveness via increase of Th1 response. CONCLUSIONS: Collectively, our data suggest that CpG-ODN treatment modulates Th2 inflammation in the lung by induction of regulatory T cells or Th1 response in a cockroach-induced asthma model. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Korean Academy of Pediatric Allergy and Respiratory Disease | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-γ? Th1 Cells or Foxp3? Regulatory T Cells in the Lung | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Do-Hyun Kim | - |
dc.contributor.googleauthor | Jung-Ho Sohn | - |
dc.contributor.googleauthor | Hong-Jai Park | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Je-Min Choi | - |
dc.identifier.doi | 10.4168/aair.2016.8.3.264 | - |
dc.contributor.localId | A03086 | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J00064 | - |
dc.identifier.eissn | 2092-7363 | - |
dc.identifier.pmid | 26922937 | - |
dc.subject.keyword | CpG-ODN | - |
dc.subject.keyword | Th2 inflammation | - |
dc.subject.keyword | cockroach allergen | - |
dc.subject.keyword | immune modulation | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 264 | - |
dc.citation.endPage | 275 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.8(3) : 264-275, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48047 | - |
dc.type.rims | ART | - |
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