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Clinicopathological Characteristics of Patients with Gastric Cancer according to the Expression of LIN28A

DC FieldValueLanguage
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.date.accessioned2017-10-26T07:37:55Z-
dc.date.available2017-10-26T07:37:55Z-
dc.date.issued2016-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152302-
dc.description.abstractBACKGROUND/AIMS: Although LIN28A is known to potentially play a role in the oncogenesis of various cancers, whether LIN28A expression is a predictor of poor prognosis in patients with gastric cancer has not been fully explored. We sought to evaluate clinicopathological characteristics according to the expression of LIN28A in numerous gastric cancer tissue samples. METHODS: LIN28A expression was evaluated by immunohistochemical (IHC) analysis of a tissue microarray comprising 288 gastric cancer tissues and 288 adjacent normal tissues. Clinicopathological characteristics, including overall survival, were compared according to LIN28A expression. RESULTS: The IHC staining score was lower for the cancer tissues than the normal tissues (p<0.001). However, no significant differences were observed in the clinicopathological characteristics between the low and high LIN28A expression groups. In addition, the 5-year overall survival rate did not differ between the two groups: 75.3% (95% confidence interval [CI], 69.3% to 81.7%) versus 71.6% (95% CI, 63.3% to 80.9%) for low versus high expression, respectively. CONCLUSIONS: The expression of LIN28A did not appear to play a distinct role in predicting the clinicopathological characteristics of patients with gastric cancer. In addition, LIN28A expression was not an independently associated factor for overall survival in patients with gastric cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherEditorial Office of Gut and Liver-
dc.relation.isPartOfGut and Liver-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Proteins/analysis*-
dc.subject.MESHPrognosis-
dc.subject.MESHRNA-Binding Proteins/analysis*-
dc.subject.MESHStomach/chemistry-
dc.subject.MESHStomach/pathology-
dc.subject.MESHStomach Neoplasms/chemistry*-
dc.subject.MESHStomach Neoplasms/mortality-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHSurvival Rate-
dc.titleClinicopathological Characteristics of Patients with Gastric Cancer according to the Expression of LIN28A-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorChan Hyuk Park-
dc.contributor.googleauthorJung Hwa Lee-
dc.contributor.googleauthorNa Keum Lee-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorSang Kil Lee-
dc.identifier.doi10.5009/gnl15283-
dc.contributor.localIdA02988-
dc.contributor.localIdA02812-
dc.relation.journalcodeJ00954-
dc.identifier.pmid26893371-
dc.subject.keywordLIN28A-
dc.subject.keywordStomach neoplasms-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.citation.volume10-
dc.citation.number5-
dc.citation.startPage714-
dc.citation.endPage718-
dc.identifier.bibliographicCitationGut and Liver, Vol.10(5) : 714-718, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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