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Some Elements in Thyroid Tissue are Associated with More Advanced Stage of Thyroid Cancer in Korean Women

Authors
 Hye-Kyung Chung  ;  Ji Sun Nam  ;  Chul Woo Ahn  ;  Yong Sang Lee  ;  Kyung Rae Kim 
Citation
 BIOLOGICAL TRACE ELEMENT RESEARCH, Vol.171(1) : 54-62, 2016 
Journal Title
 BIOLOGICAL TRACE ELEMENT RESEARCH 
ISSN
 0163-4984 
Issue Date
2016
MeSH
Adult ; Female ; Humans ; Logistic Models ; Metals, Heavy/analysis* ; Republic of Korea ; Thyroid Gland/chemistry* ; Thyroid Gland/pathology ; Thyroid Neoplasms/chemistry* ; Thyroid Neoplasms/pathology ; Trace Elements/analysis*
Keywords
Cadmium ; Heavy metals ; Thyroid cancer ; Trace elements ; Zinc
Abstract
Excessive exposure to heavy metals including cadmium and lead is known to have adverse effects on various types of cancer. The aim of the present study was to evaluate the associations between blood and tissue levels of heavy metals and trace elements and different stages of thyroid cancer in Korean women. Ninety-two Korean women undergoing thyroidectomy were included in this study. Blood and thyroid tissue levels of cadmium, lead, mercury, selenium, and zinc were measured, and histopathological results, cancer tumor node metastasis (TNM) stage, and cancer multifocality were assessed. The tissue levels of cadmium, selenium, and zinc were significantly higher in patients with TNM stages 3 and 4 compared to those in stage 1. The tissue level of cadmium was greater in patients with higher tumor stage (≥T2) than those with lower stage (T1). Also, the tissue levels of cadmium and zinc were higher in multifocal group than in unifocal group. A logistic multiple regression analysis showed that the odds ratio (OR) for advanced tumor stage group (≥T2) increased in those with higher tissue cadmium level after adjustment (OR = 1.397, 95 % CI = 1.078-1.811). The accumulation of cadmium in thyroid tissue may be one of important etiologic factors for the thyroid cancer progression and aggravation in Korean women.
Full Text
https://link.springer.com/article/10.1007%2Fs12011-015-0502-5
DOI
10.1007/s12011-015-0502-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152285
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