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Comparison of Formulas for Calculating Low-density Lipoprotein Cholesterol in General Population and High-risk Patients with Cardiovascular Disease

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dc.contributor.author김현창-
dc.contributor.author심지선-
dc.date.accessioned2017-10-26T07:36:20Z-
dc.date.available2017-10-26T07:36:20Z-
dc.date.issued2016-
dc.identifier.issn1738-5520-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152261-
dc.description.abstractBACKGROUND AND OBJECTIVES: Low-density lipoprotein cholesterol (LDL-C), an established cardiovascular risk factor, can be generally determined by calculation from total cholesterol, high-density lipoprotein cholesterol, and triglyceride concentrations. The aim of this study was to compare LDL-C estimations using various formulas with directly measured LDL-C in a community-based group and hospital-based group among the Korean population. SUBJECTS AND METHODS: A total of 1498 participants were classified into four groups according to triglyceride concentrations as follows: <100, 100-199, 200-299, and ≥300 mg/dL. LDL-C was calculated using the Friedewald, Chen, Vujovic, Hattori, de Cordova, and Anandaraja formulas and directly measured using a homogenous enzymatic method. Pearson's correlation coefficients, intraclass correlation coefficients (ICC), Passing & Bablok regression, and Bland-Altman plots were used to evaluate the performance of six formulas. RESULTS: The Friedewald formula had the highest accuracy (ICC=0.977; 95% confidence interval 0.974-0.979) of all the triglyceride ranges, while the Vujovic formula had the highest accuracy (ICC=0.876; 98.75% confidence interval 0.668-0.951) in people with triglycerides ≥300 mg/dL. The mean difference was the lowest for the Friedewald formula (0.5 mg/dL) and the percentage error was the lowest for the Vujovic formula (30.2%). However, underestimation of the LDL-C formulas increased with triglyceride concentrations. CONCLUSION: The accuracy of the LDL-C formulas varied considerably with differences in triglyceride concentrations. The Friedewald formula outperformed other formulas for estimating LDL-C against a direct measurement and the Vujovic formula was suitable for hypertriglyceridemic samples; it could be used as an alternative cost-effective tool to measure LDL-C when the direct measurement cannot be afforded.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.relation.isPartOfKOREAN CIRCULATION JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparison of Formulas for Calculating Low-density Lipoprotein Cholesterol in General Population and High-risk Patients with Cardiovascular Disease-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorHansol Choi-
dc.contributor.googleauthorJee-Seon Shim-
dc.contributor.googleauthorMyung Ha Lee-
dc.contributor.googleauthorYoung Mi Yoon-
dc.contributor.googleauthorDong Phil Choi-
dc.contributor.googleauthorHyeon Chang Kim-
dc.identifier.doi10.4070/kcj.2016.46.5.688-
dc.contributor.localIdA02212-
dc.contributor.localIdA01142-
dc.relation.journalcodeJ01952-
dc.identifier.eissn1738-5555-
dc.relation.journalsince2005~-
dc.identifier.pmid27721861-
dc.relation.journalbefore~2004 Korean Circulation Journal (순환기)-
dc.subject.keywordCholesterol-
dc.subject.keywordFriedewald formula-
dc.subject.keywordLow-density lipoprotein cholesterol-
dc.subject.keywordTriglyceride-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameShim, Jee Seon-
dc.contributor.affiliatedAuthorShim, Jee Seon-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.citation.volume46-
dc.citation.number5-
dc.citation.startPage688-
dc.citation.endPage698-
dc.identifier.bibliographicCitationKOREAN CIRCULATION JOURNAL, Vol.46(5) : 688-698, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid47997-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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