Cited 23 times in
Comparison of Formulas for Calculating Low-density Lipoprotein Cholesterol in General Population and High-risk Patients with Cardiovascular Disease
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.contributor.author | 심지선 | - |
dc.date.accessioned | 2017-10-26T07:36:20Z | - |
dc.date.available | 2017-10-26T07:36:20Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152261 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Low-density lipoprotein cholesterol (LDL-C), an established cardiovascular risk factor, can be generally determined by calculation from total cholesterol, high-density lipoprotein cholesterol, and triglyceride concentrations. The aim of this study was to compare LDL-C estimations using various formulas with directly measured LDL-C in a community-based group and hospital-based group among the Korean population. SUBJECTS AND METHODS: A total of 1498 participants were classified into four groups according to triglyceride concentrations as follows: <100, 100-199, 200-299, and ≥300 mg/dL. LDL-C was calculated using the Friedewald, Chen, Vujovic, Hattori, de Cordova, and Anandaraja formulas and directly measured using a homogenous enzymatic method. Pearson's correlation coefficients, intraclass correlation coefficients (ICC), Passing & Bablok regression, and Bland-Altman plots were used to evaluate the performance of six formulas. RESULTS: The Friedewald formula had the highest accuracy (ICC=0.977; 95% confidence interval 0.974-0.979) of all the triglyceride ranges, while the Vujovic formula had the highest accuracy (ICC=0.876; 98.75% confidence interval 0.668-0.951) in people with triglycerides ≥300 mg/dL. The mean difference was the lowest for the Friedewald formula (0.5 mg/dL) and the percentage error was the lowest for the Vujovic formula (30.2%). However, underestimation of the LDL-C formulas increased with triglyceride concentrations. CONCLUSION: The accuracy of the LDL-C formulas varied considerably with differences in triglyceride concentrations. The Friedewald formula outperformed other formulas for estimating LDL-C against a direct measurement and the Vujovic formula was suitable for hypertriglyceridemic samples; it could be used as an alternative cost-effective tool to measure LDL-C when the direct measurement cannot be afforded. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Comparison of Formulas for Calculating Low-density Lipoprotein Cholesterol in General Population and High-risk Patients with Cardiovascular Disease | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | Hansol Choi | - |
dc.contributor.googleauthor | Jee-Seon Shim | - |
dc.contributor.googleauthor | Myung Ha Lee | - |
dc.contributor.googleauthor | Young Mi Yoon | - |
dc.contributor.googleauthor | Dong Phil Choi | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.identifier.doi | 10.4070/kcj.2016.46.5.688 | - |
dc.contributor.localId | A02212 | - |
dc.contributor.localId | A01142 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.relation.journalsince | 2005~ | - |
dc.identifier.pmid | 27721861 | - |
dc.relation.journalbefore | ~2004 Korean Circulation Journal (순환기) | - |
dc.subject.keyword | Cholesterol | - |
dc.subject.keyword | Friedewald formula | - |
dc.subject.keyword | Low-density lipoprotein cholesterol | - |
dc.subject.keyword | Triglyceride | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.alternativeName | Shim, Jee Seon | - |
dc.contributor.affiliatedAuthor | Shim, Jee Seon | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Chang | - |
dc.citation.volume | 46 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 688 | - |
dc.citation.endPage | 698 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.46(5) : 688-698, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 47997 | - |
dc.type.rims | ART | - |
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