Cited 41 times in
Prevalence and Molecular Characteristics of Carbapenemase-Producing Enterobacteriaceae From Five Hospitals in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정석훈 | - |
dc.contributor.author | 홍준성 | - |
dc.date.accessioned | 2017-10-26T07:35:16Z | - |
dc.date.available | 2017-10-26T07:35:16Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152230 | - |
dc.description.abstract | BACKGROUND: The emergence of carbapenemase-producing Enterobacteriaceae (CPE) represents a major clinical problem because these bacteria are resistant to most antibiotics. CPE remain relatively uncommon in Korea. We report the prevalence, clinical characteristics, and molecular epidemiology of CPE isolates collected from five university hospitals in Korea. METHODS: Between January and December 2015, 393 non-duplicated isolates that were nonsusceptible to ertapenem were analyzed. Production of carbapenemase, extended-spectrum β-lactamase, and AmpC β-lactamase was determined by genotypic tests. Antimicrobial susceptibility profiles were determined by using an Etest. Clonality of Klebsiella pneumoniae carbapenemase (KPC)-2-producing and oxacillinase (OXA)-232-producing Klebsiella pneumoniae isolates was determined by pulsed-field gel electrophoresis (PFGE). RESULTS: Of the 393 isolates tested, 79 (20.1%) were CPE. Of these 79 isolates, 47 (59.5%) harbored the bla(OXA-232) gene while the remaining isolates carried genes bla(KPC-2) (n=27), bla(IMP-1) (n=4), and bla(NDM-1) (n=1). Among the 24 KPC-2 K. pneumoniae isolates from hospital B, 100% were resistant to carbapenems, 8% to colistin, and 0% to tigecycline. Among the 45 OXA-232 K. pneumoniae at hospital C, 95% were resistant to ertapenem, 68% to imipenem, 95% to meropenem, 10% to colistin, and 24% to tigecycline. PFGE analysis revealed a unique pattern for KPC-2 K. pneumoniae and identified 30 isolates belonging to the dominant pulsotypes (PT)1 and PT2 among 41 OXA-232 K. pneumoniae isolates. CONCLUSIONS: CPE strains are present in Korea, with the majority of K. pneumoniae isolates producing OXA-232 and KPC-2. The prevalence and predominant genotypes of CPE show hospital-specific differences. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology | - |
dc.subject.MESH | Bacterial Proteins/genetics* | - |
dc.subject.MESH | Bacterial Proteins/metabolism | - |
dc.subject.MESH | Drug Resistance, Bacterial | - |
dc.subject.MESH | Electrophoresis, Gel, Pulsed-Field | - |
dc.subject.MESH | Enterobacteriaceae/drug effects | - |
dc.subject.MESH | Enterobacteriaceae/enzymology* | - |
dc.subject.MESH | Enterobacteriaceae/isolation & purification | - |
dc.subject.MESH | Enterobacteriaceae Infections/diagnosis | - |
dc.subject.MESH | Enterobacteriaceae Infections/epidemiology | - |
dc.subject.MESH | Enterobacteriaceae Infections/microbiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Hospitals | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | beta-Lactamases/genetics* | - |
dc.subject.MESH | beta-Lactamases/metabolism | - |
dc.title | Prevalence and Molecular Characteristics of Carbapenemase-Producing Enterobacteriaceae From Five Hospitals in Korea | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Han-Sung Kim | - |
dc.contributor.googleauthor | Jae-Seok Kim | - |
dc.contributor.googleauthor | Dong Hoon Shin | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Min-Jeong Park | - |
dc.contributor.googleauthor | Saeam Shin | - |
dc.contributor.googleauthor | Jun Sung Hong | - |
dc.contributor.googleauthor | Seung Soon Lee | - |
dc.contributor.googleauthor | Wonkeun Song | - |
dc.identifier.doi | 10.3343/alm.2016.36.6.529 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.relation.journalsince | 2012~ | - |
dc.identifier.pmid | 27578505 | - |
dc.relation.journalbefore | ~2011 Korean Journal of Laboratory Medicine (대한진단검사의학회지) | - |
dc.subject.keyword | Enterobacteriaceae | - |
dc.subject.keyword | KPC-2 | - |
dc.subject.keyword | Klebsiella pneumoniae | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | OXA-232 | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.citation.volume | 36 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 529 | - |
dc.citation.endPage | 535 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.36(6) : 529-535, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 47970 | - |
dc.type.rims | ART | - |
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