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Interobserver variability in gross tumor volume delineation for hepatocellular carcinoma : Results of Korean Radiation Oncology Group 1207 study

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dc.contributor.author김준원-
dc.contributor.author이익재-
dc.contributor.author성진실-
dc.date.accessioned2017-10-26T07:34:50Z-
dc.date.available2017-10-26T07:34:50Z-
dc.date.issued2016-
dc.identifier.issn0179-7158-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152217-
dc.description.abstractPURPOSE: There has been increasing use of external beam radiotherapy for localized treatment of hepatocellular carcinoma (HCC) with both palliative and curative intent. Quality control of target delineation in primary HCC is essential to deliver adequate doses of radiation to the primary tumor while preserving adjacent healthy organs. We analyzed interobserver variability in gross tumor volume (GTV) delineation for HCC. PATIENTS AND METHODS: Twelve radiation oncologists specializing in liver malignancy participated in a multi-institutional contouring dummy-run study of nine HCC cases and independently delineated GTV on the same set of provided computed tomography images. Quantitative analysis was performed using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics calculating agreement between physicians. To quantify the interobserver variability of GTV delineations, the ratio of the actual delineated volume to the estimated consensus volume (STAPLE), the ratio of the common and encompassing volumes, and the coefficient of variation were calculated. RESULTS: The median kappa agreement level was 0.71 (range 0.28-0.86). The ratio of the actual delineated volume to the estimated consensus volume ranged from 0.19 to 1.93 (median 0.94) for all cases. The ratio of the common and encompassing volumes ranged from 0.001 to 0.56 (median 0.25). The coefficient of variation for GTV delineation ranged from 8 to 57?% (median 26?%). CONCLUSION: The interobserver variability in target delineation of HCC GTV in this study is noteworthy. Multi-institution studies involving radiotherapy for HCC require appropriate quality assurance programs for target delineation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageGerman, English, French(Summary)-
dc.publisherUrban & Vogel-
dc.relation.isPartOfSTRAHLENTHERAPIE UND ONKOLOGIE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/diagnostic imaging*-
dc.subject.MESHCarcinoma, Hepatocellular/pathology*-
dc.subject.MESHClinical Competence*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/diagnostic imaging*-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHObserver Variation-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTumor Burden*-
dc.titleInterobserver variability in gross tumor volume delineation for hepatocellular carcinoma : Results of Korean Radiation Oncology Group 1207 study-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorYoung Suk Kim-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorWon Sup Yoon-
dc.contributor.googleauthorMin Kyu Kang-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorTae Hyun Kim-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorHyung-Sik Lee-
dc.contributor.googleauthorHee Chul Park-
dc.contributor.googleauthorHong Seok Jang-
dc.contributor.googleauthorChul Seung Kay-
dc.contributor.googleauthorSang Min Yoon-
dc.contributor.googleauthorMi-Sook Kim-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1007/s00066-016-1028-2-
dc.contributor.localIdA03055-
dc.contributor.localIdA01956-
dc.contributor.localIdA00958-
dc.relation.journalcodeJ02689-
dc.identifier.eissn1439-099X-
dc.identifier.pmid27538775-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00066-016-1028-2-
dc.subject.keywordChemoembolization-
dc.subject.keywordOrgans at risk-
dc.subject.keywordQuality assurance-
dc.subject.keywordRadiofrequency ablation-
dc.subject.keywordRadiotherapy-
dc.contributor.alternativeNameKim, Jun Won-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorKim, Jun Won-
dc.citation.volume192-
dc.citation.number10-
dc.citation.startPage714-
dc.citation.endPage721-
dc.identifier.bibliographicCitationSTRAHLENTHERAPIE UND ONKOLOGIE, Vol.192(10) : 714-721, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46994-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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