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Treatment outcomes of intensity-modulated radiotherapy versus 3D conformal radiotherapy for patients with maxillary sinus cancer in the postoperative setting

Authors
 Yang-Gun Suh  ;  Chang Geol Lee  ;  Hyunju Kim  ;  Eun Chang Choi  ;  Se Hun Kim  ;  Chang-Hoon Kim  ;  Ki Chang Keum 
Citation
 Head & Neck, Vol.38(Suppl. 1) : 207-213, 2016 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2016
MeSH
Adult ; Aged ; Carcinoma, Adenoid Cystic/radiotherapy ; Carcinoma, Squamous Cell/radiotherapy ; Female ; Humans ; Male ; Maxillary Sinus Neoplasms/radiotherapy* ; Middle Aged ; Radiotherapy Dosage ; Radiotherapy, Conformal* ; Radiotherapy, Intensity-Modulated* ; Treatment Outcome
Keywords
3D conformal radiotherapy (RT) ; intensity-modulated radiotherapy (IMRT) ; maxillary sinus cancer ; maxillectomy ; paranasal sinus
Abstract
BACKGROUND: In this study, we compared the treatment outcomes of postoperative 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) for patients with maxillary sinus carcinoma. METHODS: Fifty-four patients underwent surgery and postoperative RT, of whom 27 (50%) had squamous cell carcinoma and 14 (26%) had adenoid cystic carcinoma. Nineteen patients (35%) were treated with IMRT and 35 patients (65%) received 3D conformal RT. The median radiation dose for 3D conformal RT and IMRT were 62.1 and 63 Gy, respectively. RESULTS: IMRT produced significantly superior radiation dose distribution to planning target volumes (PTVs) than 3D conformal RT. Over a median follow-up of 60 months, IMRT provided better 3-year locoregional recurrence-free survival (89.2% vs 59.5%; p = .035) and distant metastasis-free survival (94.7% vs 55.3%; p = .042) rates than 3D conformal RT. CONCLUSION: Postoperative IMRT for patients with maxillary sinus carcinoma resulted in excellent disease control, and should be considered as the first treatment option in these cases.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.23971/abstract
DOI
10.1002/hed.23971
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
금기창(Keum, Ki Chang) ORCID logo https://orcid.org/0000-0003-4123-7998
김창훈(Kim, Chang Hoon) ORCID logo https://orcid.org/0000-0003-1238-6396
김현주(Kim, Hyun Ju)
이창걸(Lee, Chang Geol) ORCID logo https://orcid.org/0000-0002-8702-881X
최은창(Choi, Eun Chang)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152211
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