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Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation

DC Field Value Language
dc.contributor.author김수희-
dc.contributor.author오은지-
dc.contributor.author윤선옥-
dc.contributor.author양우익-
dc.date.accessioned2017-10-26T07:34:23Z-
dc.date.available2017-10-26T07:34:23Z-
dc.date.issued2016-
dc.identifier.issn2383-7837-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152209-
dc.description.abstractBACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3). Deregulation of c-MYC and interaction between c-MYC and EZH2 are well known in lymphomagenesis; however, little is known about the expression status of HOTAIR in diffuse large B-cell lymphomas (DLBCLs). METHODS: The expression status of PRC2 (EZH2, SUZ12, and EED), H3K27me3, c-MYC, and BCL2 was analyzed using immunohistochemistry (n = 231), and HOTAIR was investigated by a quantification real-time polymerase chain reaction method (n = 164) in DLBCLs. RESULTS: The present study confirmed the positive correlation among PRC2 proteins, H3K27me3, and c-MYC in DLBCLs. Expression level of HOTAIR was also positively correlated to EZH2 (p < .05, respectively). Between c-MYC and HOTAIR, and between c- MYC/BCL2 co-expression and HOTAIR, however, negative correlation was observed in DLBCLs (p < .05, respectively). High level of H3K27me3 was determined as an independent prognostic marker in poor overall survival (hazard ratio, 2.0; p = .023) of DLBCL patients. High expression of HOTAIR, however, was associated with favorable overall survival (p = .004) in the univariate analysis, but the impact was not significant in the multivariate analysis. The favorable outcome of DLBCL with HOTAIR high expression levels may be related to the negative correlation with c- MYC expression or c-MYC/BCL2 co-expression. CONCLUSIONS: HOTAIR expression could be one of possible mechanisms for inducing H3K27me3 via EZH2-related PRC2 activation, and induced H3K27me3 may be strongly related to aggressive DLBCLs which show poor patient outcome.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherThe Korean Society of Pathologists-
dc.relation.isPartOfJOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLong Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorEun Ji Oh-
dc.contributor.googleauthorSoo Hee Kim-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorYoung Hyeh Ko-
dc.contributor.googleauthorSun Och Yoon-
dc.identifier.doi10.4132/jptm.2016.06.06-
dc.contributor.localIdA04606-
dc.contributor.localIdA02566-
dc.contributor.localIdA02300-
dc.contributor.localIdA00644-
dc.relation.journalcodeJ01680-
dc.identifier.eissn2383-7845-
dc.relation.journalsince2015~-
dc.identifier.pmid27550047-
dc.relation.journalbefore~2014 Korean Journal of Pathology-
dc.subject.keywordHOTAIR-
dc.subject.keywordHistone H3trimethylation at lysine 27-
dc.subject.keywordLymphoma, large B-cell, diffuse-
dc.subject.keywordPolycomb repressive complex2-
dc.subject.keywordhox transcript antisense intergenic RNA-
dc.contributor.alternativeNameKim, Soo Hee-
dc.contributor.alternativeNameOh, Eun Ji-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.affiliatedAuthorOh, Eun Ji-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorKim, Soo Hee-
dc.citation.volume50-
dc.citation.number5-
dc.citation.startPage369-
dc.citation.endPage376-
dc.identifier.bibliographicCitationJOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.50(5) : 369-376, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46986-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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