Cited 37 times in
Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 홍성필 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 이현정 | - |
dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2017-10-26T07:30:56Z | - |
dc.date.available | 2017-10-26T07:30:56Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152131 | - |
dc.description.abstract | BACKGROUND/AIMS: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown beneficial effects in experimental colitis models, but the underlying mechanisms are not fully understood. We investigated the long-term effects of BM-MSCs, particularly in mice with chronic colitis. METHODS: Chronic colitis was induced by administering 3% dextran sulfate sodium (DSS) in a series of three cycles. BMMSCs were injected intravenously into DSS-treated mice three times during the first cycle. On day 33, the therapeutic effects were evaluated with clinicopathologic profiles and histological scoring. Inflammatory mediators were measured with real-time polymerase chain reaction. RESULTS: Systemic infusion of BM-MSCs ameliorated the severity of colitis, and body weight restoration was significantly promoted in the BMMSC- treated mice. In addition, BM-MSC treatment showed a sustained beneficial effect throughout the three cycles. Microscopic examination revealed that the mice treated with BM-MSCs had fewer inflammatory infiltrates, a lesser extent of inflammation, and less crypt structure damage compared with mice with DSS-induced colitis. Anti-inflammatory cytokine levels of interleukin-10 were significantly increased in the inflamed colons of BM-MSC-treated mice compared with DSS-induced colitis mice. CONCLUSIONS: Systemic infusion of BM-MSCs at the onset of disease exerted preventive and rapid recovery effects, with long-term immunosuppressive action in mice with repeated DSS-induced chronic colitis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Colitis/chemically induced | - |
dc.subject.MESH | Colitis/prevention & control* | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Dextran Sulfate/toxicity | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Irritants/toxicity | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/physiology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.title | Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hyun Jung Lee | - |
dc.contributor.googleauthor | Sun-Hee Oh | - |
dc.contributor.googleauthor | Hui Won Jang | - |
dc.contributor.googleauthor | Ji-Hee Kwon | - |
dc.contributor.googleauthor | Kyoung Jin Lee | - |
dc.contributor.googleauthor | Chung Hee Kim | - |
dc.contributor.googleauthor | Soo Jung Park | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 10.5009/gnl15229 | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A01539 | - |
dc.contributor.localId | A03295 | - |
dc.contributor.localId | A04030 | - |
dc.contributor.localId | A00774 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 27114436 | - |
dc.subject.keyword | Bone marrow | - |
dc.subject.keyword | Chronic colitis | - |
dc.subject.keyword | Dextran sulfate sodium | - |
dc.subject.keyword | Inflammatory bowel disease | - |
dc.subject.keyword | Mesenchymal stem cell | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Park, Soo Jung | - |
dc.contributor.alternativeName | Lee, Hyun Jung | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Park, Soo Jung | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 412 | - |
dc.citation.endPage | 419 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.10(3) : 412-419, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46911 | - |
dc.type.rims | ART | - |
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