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Prognostic significance and frequency of EGFR expression and amplification in surgically resected advanced gastric cancer

DC FieldValueLanguage
dc.contributor.author김현기-
dc.contributor.author김효송-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author정재호-
dc.contributor.author박지수-
dc.date.accessioned2017-10-26T07:29:02Z-
dc.date.available2017-10-26T07:29:02Z-
dc.date.issued2016-
dc.identifier.issn0368-2811-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152091-
dc.description.abstractOBJECTIVE: The aim of this study is to find the frequency and the role of epidermal growth factor receptor expression as a prognostic biomarker in gastric cancer. METHODS: We evaluated the prognostic value and frequency of epidermal growth factor receptor expression and amplification using immunohistochemistry and silver in situ hybridization in a large cohort of curatively resected gastric cancer. RESULTS: Of the total of 935 cases, 294 (31.4%), 101 (10.8%) and 36 (3.9%) patients showed epidermal growth factor receptor 1+, 2+ and 3+ expression on immunohistochemistry, respectively. Epidermal growth factor receptor-positive (2+/3+) patients more frequently had intestinal type than epidermal growth factor receptor-negative (0/1+) patients (82.5 vs. 44.1%, P < 0.001). After adjusting for sex, age, stage and adjuvant chemotherapy, epidermal growth factor receptor-positive patients had a favorable overall survival outcome compared with epidermal growth factor receptor-negative patients (hazard ratio, 0.734; 95% confidence interval, 0.541-0.997; P = 0.047), especially in Stage III disease (hazard ratio, 0.676; 95% confidence interval, 0.472-0.968; P = 0.033). Among the 393 cases available for in situ hybridization, the correlation between immunohistochemistry and in situ hybridization was statistically significant (P = 0.001). Thirteen patients with gene amplification (3.3%) did not show different survival outcome with others (P = 0.359). CONCLUSION: Epidermal growth factor receptor positivity was an independent favorable prognostic factor for gastric cancer, especially in Stage III disease.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfJAPANESE JOURNAL OF CLINICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor/genetics-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHCisplatin/therapeutic use-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHDoxorubicin/therapeutic use-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHFluorouracil/therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptor, ErbB-2/genetics-
dc.subject.MESHReceptor, ErbB-2/metabolism*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSilver/chemistry-
dc.subject.MESHStomach Neoplasms/diagnosis*-
dc.subject.MESHStomach Neoplasms/drug therapy-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHSurvival Rate-
dc.titlePrognostic significance and frequency of EGFR expression and amplification in surgically resected advanced gastric cancer-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJi Soo Park-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorYoon Sung Bae-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyunki Kim-
dc.identifier.doi10.1093/jjco/hyw030-
dc.contributor.localIdA01202-
dc.contributor.localIdA01281-
dc.contributor.localIdA01316-
dc.contributor.localIdA03717-
dc.contributor.localIdA01108-
dc.relation.journalcodeJ01207-
dc.identifier.eissn1465-3621-
dc.identifier.pmid27008850-
dc.identifier.urlhttps://academic.oup.com/jjco/article-lookup/doi/10.1093/jjco/hyw030-
dc.subject.keywordbiological markers-
dc.subject.keywordreceptor, epidermal growth factor-
dc.subject.keywordrognosis-
dc.subject.keywordstomach neoplasms-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.citation.volume46-
dc.citation.number6-
dc.citation.startPage507-
dc.citation.endPage516-
dc.identifier.bibliographicCitationJAPANESE JOURNAL OF CLINICAL ONCOLOGY, Vol.46(6) : 507-516, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46871-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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