Cited 9 times in
Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 장혁재 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 유희태 | - |
dc.date.accessioned | 2017-10-26T07:28:51Z | - |
dc.date.available | 2017-10-26T07:28:51Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152086 | - |
dc.description.abstract | PURPOSE: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with cardiovascular disease (CVD). A recent study showed that sST2 predicted incident hypertension. High sensitive C-reactive protein (hsCRP) has been a widely-used biomarker for risk-stratifying in CVD. We compared the abilities of sST2 and hsCRP to predict high risk coronary artery calcium score (CACS). MATERIALS AND METHODS: The CACS was assessed by cardiac computed tomography, and sST2 was measured in 456 subjects enrolled in the Mapo-gu community cohort. In accordance with the 2013 ACC/AHA guidelines, we defined the high risk CACS group as individuals with a CACS ≥300 Agatston units (AU). RESULTS: There were 99 (21.7%) subjects with a CACS ≥300 AU. There was a strong correlation between log sST2 and log hsCRP (r=0.128, p=0.006), and both log sST2 and log hsCRP showed significant associations with CACS (r=0.101, p=0.031 for sST2, r=0.101, p=0.032 for hsCRP). In net reclassification improvement (NRI) analysis, the NRI for hsCRP over sST2 was significant [continuous NRI 0.238, 95% confidence interval (CI) 0.001-0.474, integrated discrimination index (IDI) 0.022, p=0.035], while the NRI for sST2 over hsCRP was not significant (continuous NRI 0.212, 95% CI -0.255-0.453, IDI 0.002, p=0.269). CONCLUSION: sST2 does not improve net reclassification for predicting a high risk CACS. Using hsCRP provides superior discrimination and risk reclassification for coronary atherosclerosis, compared with sST2. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | C-Reactive Protein/analysis* | - |
dc.subject.MESH | Calcium | - |
dc.subject.MESH | Computed Tomography Angiography | - |
dc.subject.MESH | Coronary Angiography/methods* | - |
dc.subject.MESH | Coronary Artery Disease/diagnostic imaging* | - |
dc.subject.MESH | Coronary Vessels/diagnostic imaging* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-1 Receptor-Like 1 Protein | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Population Surveillance | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.subject.MESH | Vascular Calcification/diagnostic imaging* | - |
dc.title | Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.identifier.doi | 10.3349/ymj.2016.57.6.1347 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A02535 | - |
dc.contributor.localId | A00037 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 27593861 | - |
dc.subject.keyword | Soluble ST2 | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | coronary artery calcium score | - |
dc.subject.keyword | high sensitive C-reactive protein | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Oh, Jae Won | - |
dc.contributor.alternativeName | Yu, Hee Tae | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Oh, Jae Won | - |
dc.contributor.affiliatedAuthor | Yu, Hee Tae | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1347 | - |
dc.citation.endPage | 1353 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(6) : 1347-1353, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46866 | - |
dc.type.rims | ART | - |
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