Cited 3 times in
Makorin Ring Finger Protein 1 as Adjunctive Marker in Liquid-based Cervical Cytology
DC Field | Value | Language |
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dc.contributor.author | 김재훈 | - |
dc.contributor.author | 장민영 | - |
dc.contributor.author | 조한별 | - |
dc.contributor.author | 채두병 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2017-10-26T07:28:29Z | - |
dc.date.available | 2017-10-26T07:28:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152077 | - |
dc.description.abstract | To assess the utility of makorin ring finger protein 1 (MKRN1) as a marker of cervical pathology.A PROspective specimen collection and retrospective Blinded Evaluation study was conducted. Liquid-based cytology samples were collected from 187 women, embedding all residuals as cell blocks for immunohistochemical staining of MKRN1 and P16 . Results of liquid-based cervical cytology, immunostained cell block sections, and human papillomavirus (HPV) hybrid capture (with real-time polymerase chain reaction) were analyzed. Clinical outcomes were analyzed overall and in subsets of specimens yielding atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions.Makorin ring finger protein 1 positivity and grades (1-3) of cervical intraepithelial neoplasia (CIN) increased in tandem (CIN1, 32.4%; CIN2, 60.0%; and CIN3, 80.0%), reaching 92.3% in invasive cancer. Sensitivity, specificity, positive predictive value, and negative predictive value in detecting CIN2+ via MKRN1 were 73.8%, 76.8%, 75.6%, and 75.0%, respectively. The performance of liquid-based cytology was poorer by comparison (61.3%, 69.5%, 66.2%, and 64.8%, respectively), and HPV assay (versus MKRN1 immunohistochemical staining) displayed lower specificity (67.7%). Combined HPV?+?MKRN1 testing proved highest in sensitivity, specificity, positive predictive value, and negative predictive value (71.8%, 85.5%, 82.3%, and 76.5%, respectively), whereas corresponding values for cytology?+?HPV (60.6%, 81.8%, 75.4%, and 69.2%) and cytology?+?MKRN1 (58.8%, 84.1%, 78.3%, and 67.7%) were all similar. In instances of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions, the HPV?+?MKRN1 combination performed best by above measures (100%, 72.7%, 73.9%, and 100%), followed by cytology?+?MKRN1 (100%, 50.0%, 60.7%, and 100%).Makorin ring finger protein 1 displayed greater sensitivity and specificity than liquid-based cytology and proved more specific than HPV assay. In combination testing, MKRN1?+?HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/diagnosis* | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/metabolism | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/virology | - |
dc.subject.MESH | Cervix Uteri/pathology | - |
dc.subject.MESH | Cervix Uteri/virology | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p16 | - |
dc.subject.MESH | Early Detection of Cancer/methods* | - |
dc.subject.MESH | False Positive Reactions | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Proteins/metabolism | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism* | - |
dc.subject.MESH | Papillomaviridae/genetics | - |
dc.subject.MESH | Papillomaviridae/isolation & purification | - |
dc.subject.MESH | Papillomavirus Infections/diagnosis* | - |
dc.subject.MESH | Papillomavirus Infections/metabolism | - |
dc.subject.MESH | Papillomavirus Infections/virology | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Ribonucleoproteins/metabolism* | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Uterine Cervical Neoplasms/diagnosis* | - |
dc.subject.MESH | Uterine Cervical Neoplasms/metabolism | - |
dc.subject.MESH | Uterine Cervical Neoplasms/virology | - |
dc.title | Makorin Ring Finger Protein 1 as Adjunctive Marker in Liquid-based Cervical Cytology | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology | - |
dc.contributor.googleauthor | Maria Lee | - |
dc.contributor.googleauthor | Min Young Chang | - |
dc.contributor.googleauthor | Ha-Yeon Shin | - |
dc.contributor.googleauthor | Eunah Shin | - |
dc.contributor.googleauthor | Sun Won Hong | - |
dc.contributor.googleauthor | Kyung-Mi Kim | - |
dc.contributor.googleauthor | Doo Byung Chay | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.identifier.doi | 10.1097/MD.0000000000002425 | - |
dc.contributor.localId | A05026 | - |
dc.contributor.localId | A03921 | - |
dc.contributor.localId | A04015 | - |
dc.contributor.localId | A04411 | - |
dc.contributor.localId | A00876 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 26817873 | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Chang, Min Young | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.alternativeName | Chay, Doo Byung | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Chang, Min Young | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Chay, Doo Byung | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.citation.volume | 95 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 2425 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.95(3) : 2425, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46857 | - |
dc.type.rims | ART | - |
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