Cited 9 times in
Early Attempts to Eradicate Helicobacter pylori after Endoscopic Resection of Gastric Neoplasm Significantly Improve Eradication Success Rates
DC Field | Value | Language |
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dc.contributor.author | 김지현 | - |
dc.contributor.author | 박재준 | - |
dc.contributor.author | 박효진 | - |
dc.contributor.author | 윤영훈 | - |
dc.contributor.author | 정다현 | - |
dc.contributor.author | 허철웅 | - |
dc.date.accessioned | 2017-10-26T07:26:03Z | - |
dc.date.available | 2017-10-26T07:26:03Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152021 | - |
dc.description.abstract | PURPOSE: After endoscopic resection (ER) of gastric tumors, eradication of Helicobacter pylori (H. pylori) infection is advised to reduce metachronous recurrence. Optimal timing of such therapy (yet to be established) was investigated herein, examining early active and late scarring stages of post-ER iatrogenic ulcers. MATERIALS AND METHODS: Analysis included 514 patients who received proton-pump inhibitor (PPI)-based triple therapy for H. pylori eradication after ER for gastric neoplasms between January 2008 and June 2015. Clinicopathologic characteristics, particularly the timing of triple therapy, were used to compare eradication rates, assigning patients to early- (≤2 weeks), intermediate- (2-8 weeks), and late-phase (≥8 weeks) treatment groups. RESULTS: H. pylori eradication rates differed significantly by timing of triple therapy after ER (early, 90.0%; intermediate, 76.2%, late, 72.4%; p <.001). However, eradication success rates were not significantly affected by age, smoking, alcohol consumption, preexisting comorbidity, method of ER, size and location of iatrogenic ulcer, and duration of therapeutic regimen. Early initiation of H. pylori eradication was also identified as a significant independent predictor of eradication success in multivariate analysis (Odds ratio = 3.67, 95% CI 2.18-6.16; p <.001). CONCLUSION: In patients undergoing ER of gastric tumors, early post-ER attempts at eradication of H. pylori offer the best chance of eradication success. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Amoxicillin/therapeutic use* | - |
dc.subject.MESH | Anti-Bacterial Agents/therapeutic use* | - |
dc.subject.MESH | Anti-Ulcer Agents/therapeutic use* | - |
dc.subject.MESH | Clarithromycin/therapeutic use* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Endoscopy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Helicobacter Infections/complications | - |
dc.subject.MESH | Helicobacter Infections/drug therapy* | - |
dc.subject.MESH | Helicobacter Infections/pathology | - |
dc.subject.MESH | Helicobacter pylori | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/prevention & control | - |
dc.subject.MESH | Proton Pump Inhibitors/therapeutic use* | - |
dc.subject.MESH | Stomach Neoplasms/complications | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/surgery* | - |
dc.subject.MESH | Time-to-Treatment | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Early Attempts to Eradicate Helicobacter pylori after Endoscopic Resection of Gastric Neoplasm Significantly Improve Eradication Success Rates | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Cheal Wung Huh | - |
dc.contributor.googleauthor | Young Hoon Youn | - |
dc.contributor.googleauthor | Da Hyun Jung | - |
dc.contributor.googleauthor | Jae Jun Park | - |
dc.contributor.googleauthor | Jie-Hyun Kim | - |
dc.contributor.googleauthor | Hyojin Park | - |
dc.identifier.doi | 10.1371/journal.pone.0162258 | - |
dc.contributor.localId | A01636 | - |
dc.contributor.localId | A01774 | - |
dc.contributor.localId | A02583 | - |
dc.contributor.localId | A03591 | - |
dc.contributor.localId | A05070 | - |
dc.contributor.localId | A00996 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 27588679 | - |
dc.contributor.alternativeName | Kim, Ji Hyun | - |
dc.contributor.alternativeName | Park, Jae Jun | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.alternativeName | Youn, Young Hoon | - |
dc.contributor.alternativeName | Jung, Da Hyun | - |
dc.contributor.alternativeName | Huh, Cheal Wung | - |
dc.contributor.affiliatedAuthor | Park, Jae Jun | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Youn, Young Hoon | - |
dc.contributor.affiliatedAuthor | Jung, Da Hyun | - |
dc.contributor.affiliatedAuthor | Huh, Cheal Wung | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hyun | - |
dc.citation.volume | 11 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e0162258 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(9) : e0162258, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46343 | - |
dc.type.rims | ART | - |
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