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Patient-controlled Analgesia With Propacetamol-Fentanyl Mixture for Prevention of Postoperative Nausea and Vomiting in High-risk Patients Undergoing Spine Surgery: A Randomized Controlled Trial

DC FieldValueLanguage
dc.contributor.author곽영란-
dc.contributor.author김은정-
dc.contributor.author소사라-
dc.contributor.author송종욱-
dc.contributor.author심재광-
dc.date.accessioned2017-10-26T07:24:42Z-
dc.date.available2017-10-26T07:24:42Z-
dc.date.issued2016-
dc.identifier.issn0898-4921-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151996-
dc.description.abstractBACKGROUND: This randomized trial evaluated the effect of intravenous patient-controlled analgesia (IV-PCA) based on fentanyl mixed with either propacetamol or an equivalent volume of normal saline on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing spinal surgery. MATERIALS AND METHODS: One hundred eight nonsmoking female patients were randomly and evenly allocated to receive IV-PCA with either propacetamol (4 g) or normal saline mixed to fentanyl (20 μg/kg). Primary study outcome was PONV incidence at 24 hours postsurgery. Secondary outcomes were nausea severity, pain intensity (100-mm visual analog scale), use of rescue antiemetics and analgesics, patient satisfaction, and adverse events at 6, 12, and 24 hours postsurgery. RESULTS: Postsurgery, the propacetamol versus normal saline group had lower PONV incidence at 24 hours (41% vs. 66%, P=0.011); pain intensity at rest and rescue analgesic requirements at 6 to 12 hours (30±15 vs. 41±19, P=0.008; and 25% vs. 49%, P=0.036, respectively) and at 12 to 24 hours (25±15 vs. 35±17, P=0.008; and 19% vs. 42%, P=0.044, respectively); and higher patient satisfaction score (6.4±1.4 vs. 5.7±1.8, P=0.028). CONCLUSIONS: In patients undergoing spinal surgery and at risk of developing PONV, continuous IV-PCA based on propacetamol mixed to fentanyl, relative to fentanyl alone, effectively reduced the incidence of PONV, pain intensity at rest, and additional use of rescue analgesics with higher patient satisfaction.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfJournal of Neurosurgical Anesthesiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAgmatine/pharmacology*-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHBrain/drug effects*-
dc.subject.MESHDiabetes Mellitus, Experimental-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHInflammation/prevention & control*-
dc.subject.MESHIschemic Attack, Transient/drug therapy*-
dc.subject.MESHMale-
dc.subject.MESHNeuroprotective Agents/pharmacology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.titlePatient-controlled Analgesia With Propacetamol-Fentanyl Mixture for Prevention of Postoperative Nausea and Vomiting in High-risk Patients Undergoing Spine Surgery: A Randomized Controlled Trial-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorKim, Eun Jung-
dc.contributor.googleauthorShim, Jae-Kwang-
dc.contributor.googleauthorSoh, Sarah-
dc.contributor.googleauthorSong, Jong Wook-
dc.contributor.googleauthorLee, Se Ryeon-
dc.contributor.googleauthorKwak, Young-Lan-
dc.identifier.doi10.1097/ANA.0000000000000252-
dc.contributor.localIdA00816-
dc.contributor.localIdA01960-
dc.contributor.localIdA02060-
dc.contributor.localIdA02205-
dc.contributor.localIdA00172-
dc.relation.journalcodeJ01639-
dc.identifier.pmid26558356-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00008506-201610000-00007&LSLINK=80&D=ovft-
dc.subject.keywordagmatine-
dc.subject.keyworddiabetes-
dc.subject.keywordinflammation-
dc.subject.keywordinnate immunity-
dc.subject.keywordischemia-reperfusion injury-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameKim, Eun Jung-
dc.contributor.alternativeNameSoh, Sa Rah-
dc.contributor.alternativeNameSong, Jong Wook-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.affiliatedAuthorKim, Eun Jung-
dc.contributor.affiliatedAuthorSoh, Sa Rah-
dc.contributor.affiliatedAuthorSong, Jong Wook-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.citation.volume28-
dc.citation.number4-
dc.citation.startPage316-
dc.citation.endPage322-
dc.identifier.bibliographicCitationJournal of Neurosurgical Anesthesiology, Vol.28(4) : 316-322, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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