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Serum clusterin level in children with atopic dermatitis

Authors
 Sol, In Suk  ;  Kim, Yoon Hee  ;  Lee, Kyung Eun  ;  Hong, Jung Yeon  ;  Kim, Mi Na  ;  Kim, Yun Seon  ;  Oh, Mi Seon  ;  Kim, Min Jung  ;  Yoon, Seo Hee  ;  Park, Young A.  ;  Kim, Kyung Won  ;  Sohn, Myung Hyun  ;  Kim, Kyu-Earn 
Citation
 Allergy and Asthma Proceedings, Vol.37(4) : 335-339, 2016 
Journal Title
 Allergy and Asthma Proceedings 
ISSN
 1088-5412 
Issue Date
2016
MeSH
Biomarkers ; Case-Control Studies ; Child ; Child, Preschool ; Clusterin/blood* ; Dermatitis, Atopic/blood* ; Dermatitis, Atopic/diagnosis* ; Eosinophils ; Female ; Humans ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Infant ; Leukocyte Count ; Male ; Severity of Illness Index
Keywords
Clusterin ; SCORAD index ; atopic dermatitis ; biomarker ; children ; eosinophil ; oxidative stress ; severity ; specific IgE ; total IgE
Abstract
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a marker to assess inflammatory diseases. The clusterin levels in AD have not been evaluated thus far. OBJECTIVE: We evaluated serum clusterin levels in children with AD and assessed the relationship between serum clusterin levels and the severity of AD. METHOD: The study enrolled a total 140 children, of whom 100 had AD (n = 100) and 40 were healthy (n = 40). The severity of AD was scored by using the SCORing Atopic Dermatitis (SCORAD). Total serum immunoglobulin E and specific immunoglobulin E levels against egg whites, cow's milk, peanuts, soybeans, wheat, and Dermatophagoides farinae were measured. Clusterin levels in serum were measured by enzyme-linked immunosorbent assay. RESULTS: The mean (interquartile range) age of the children was 5.1 years (1.3-8.4 years), and 92 (69.3%) of the children were boys. The mean (standard deviation) SCORAD index was 50.4 ± 17. The mean (standard deviation) clusterin level of children with AD was higher than that in the healthy control group children (148.13 ± 4.3 pg/mL versus 144.85 ± 5.1 pg/mL; p = 0.001). Serum clusterin levels were correlated with the SCORAD index (r = 0.327, p = 0.002). CONCLUSIONS: The serum clusterin level was higher in children with AD than in the healthy control group and increased with the severity of AD. Serum clusterin may be a candidate molecule that reflects AD and its severity.
Full Text
http://www.ingentaconnect.com/content/ocean/aap/2016/00000037/00000004/art00016
DOI
10.2500/aap.2016.37.3953
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
김민정(Kim, Min Jung) ORCID logo https://orcid.org/0000-0002-5634-9709
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
박영아(Park, Young A)
설인숙(Sol, In Suk) ORCID logo https://orcid.org/0000-0003-2470-9682
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
윤서희(Yoon, Seo Hee) ORCID logo https://orcid.org/0000-0002-8361-9815
홍정연(Hong, Jung Yeon) ORCID logo https://orcid.org/0000-0003-0406-9956
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151994
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