Cited 13 times in
The Orphan Nuclear Receptor ERRγ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression
DC Field | Value | Language |
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dc.contributor.author | 이명식 | - |
dc.date.accessioned | 2017-10-26T07:24:13Z | - |
dc.date.available | 2017-10-26T07:24:13Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151983 | - |
dc.description.abstract | BACKGROUND: Fibroblast growth factor 21 (FGF21), a stress inducible hepatokine, is synthesized in the liver and plays important roles in glucose and lipid metabolism. However, the mechanism of hepatic cannabinoid type 1 (CB1) receptor-mediated induction of FGF21 gene expression is largely unknown. RESULTS: Activation of the hepatic CB1 receptor by arachidonyl-2'-chloroethylamide (ACEA), a CB1 receptor selective agonist, significantly increased FGF21 gene expression. Overexpression of estrogen-related receptor (ERR) γ increased FGF21 gene expression and secretion both in hepatocytes and mice, whereas knockdown of ERRγ decreased ACEA-mediated FGF21 gene expression and secretion. Moreover, ERRγ, but not ERRα and ERRβ, induced FGF21 gene promoter activity. In addition, deletion and mutation analysis of the FGF21 promoter identified a putative ERRγ-binding motif (AGGTGC, a near-consensus response element). A chromatin immunoprecipitation assay revealed direct binding of ERRγ to the FGF21 gene promoter. Finally, GSK5182, an ERRγ inverse agonist, significantly inhibited hepatic CB1 receptor-mediated FGF21 gene expression and secretion. CONCLUSION: Based on our data, we conclude that ERRγ plays a key role in hepatic CB1 receptor-mediated induction of FGF21 gene expression and secretion. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Fibroblast Growth Factors/genetics* | - |
dc.subject.MESH | Gene Expression Regulation*/drug effects | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Hepatocytes/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Orphan Nuclear Rceptors/genetics | - |
dc.subject.MESH | Orphan Nuclear Receptors/metabolism* | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Receptor, Cannabinoid, CB1/agonists | - |
dc.subject.MESH | Receptor, Cannabinoid, CB1/metabolism* | - |
dc.subject.MESH | Receptors, Estrogen/genetics | - |
dc.subject.MESH | Receptors, Estrogen/metabolism* | - |
dc.subject.MESH | Tamoxifen/analogs & derivatives | - |
dc.subject.MESH | Tamoxifen/pharmacology | - |
dc.title | The Orphan Nuclear Receptor ERRγ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Yoon Seok Jung | - |
dc.contributor.googleauthor | Ji-Min Lee | - |
dc.contributor.googleauthor | Don-Kyu Kim | - |
dc.contributor.googleauthor | Yong-Soo Lee | - |
dc.contributor.googleauthor | Ki-Sun Kim | - |
dc.contributor.googleauthor | Yong-Hoon Kim | - |
dc.contributor.googleauthor | Jina Kim | - |
dc.contributor.googleauthor | Myung-Shik Lee | - |
dc.contributor.googleauthor | In-Kyu Lee | - |
dc.contributor.googleauthor | Seong Heon Kim | - |
dc.contributor.googleauthor | Sung Jin Cho | - |
dc.contributor.googleauthor | Won-Il Jeong | - |
dc.contributor.googleauthor | Chul-Ho Lee | - |
dc.contributor.googleauthor | Robert A. Harris | - |
dc.contributor.googleauthor | Hueng-Sik Choi | - |
dc.identifier.doi | 10.1371/journal.pone.0159425 | - |
dc.contributor.localId | A02752 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 27455076 | - |
dc.contributor.alternativeName | Lee, Myung Shik | - |
dc.contributor.affiliatedAuthor | Lee, Myung Shik | - |
dc.citation.volume | 11 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | e0159425 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(7) : e0159425, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46305 | - |
dc.type.rims | ART | - |
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