174 202

Cited 7 times in

Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation

Authors
 Juhyun Song  ;  Yumi Oh  ;  Jong Youl Kim  ;  Kyoung Joo Cho  ;  Jong Eun Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.57(6) : 1461-1467, 2016 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2016
MeSH
Agmatine/pharmacology* ; Cell Differentiation/drug effects* ; Cell Proliferation ; Humans ; MicroRNAs/metabolism* ; Neural Stem Cells/cytology ; Neural Stem Cells/drug effects* ; Neurogenesis/drug effects* ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism
Keywords
DCX ; ERK ; Neural stem cell (NSCs) ; TLX ; agmatine ; microRNA let-7a (let-7a)
Abstract
Purpose : Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods : This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results : Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion : Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.
Files in This Item:
T201603289.pdf Download
DOI
10.3349/ymj.2016.57.6.1461
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151966
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links