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Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author정우희-
dc.date.accessioned2017-10-26T07:23:00Z-
dc.date.available2017-10-26T07:23:00Z-
dc.date.issued2016-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151955-
dc.description.abstractCancer-associated fibroblasts (CAFs) are classified into various functional subtypes such as fibroblast activation protein-α (FAP-α), fibroblast specific protein-1 (FSP-1), platelet-derived growth factor receptor-α (PDGFR-α), and PDGFR-β. In this study, we compared the expression of CAF-related proteins in invasive lobular carcinoma (ILC) with those in invasive carcinoma of no special type (NST) and assessed the implications of the differences observed. Using tissue microarrays of 104 ILC and 524 invasive carcinoma (NST) cases, immunohistochemistry for CAF-related proteins [podoplanin, prolyl 4-hydroxylase, FAP-α, FSP-1/S100A4, PDGFR-α, PDGFR-β, and chondroitin sulfate proteoglycan (NG2)] was conducted. In invasive carcinoma (NST), tumor cells expressed a high level of PDGFR-α, whereas ILC tumor cells expressed high levels of podoplanin, prolyl 4-hydroxylase, FAP-α, and FSP-1/S100A4. In stromal cells of invasive carcinoma (NST), high expression levels of prolyl 4-hydroxylase, PDGFR-α, and NG2 were observed, whereas ILC stromal cells expressed high levels of FAP-α, FSP-1/S100A4, and PDGFR-β. In ILC, tumoral FSP-1/S100A4 positivity was associated with higher Ki-67 labeling index (p = 0.010) and non-luminal A type cancer (p = 0.014). Stromal PDGFR-α positivity was associated with lymph node metastasis (p = 0.011). On survival analysis of entire cases, tumoral FSP-1/S100A4 positivity (p = 0.002), stromal podoplanin positivity (p = 0.041), and stromal FSP-1/S100A4 negativity (p = 0.041) were associated with shorter disease-free survival; only tumoral FSP-1/S100A4 positivity (p = 0.044) was associated with shorter overall survival. In ILC, the expression of FAP-α and FSP-1/S100A4 was higher in both tumor and stromal cells than that observed in invasive carcinoma (NST). These results indicate that CAFs are a potential target in ILC treatment.-
dc.description.statementOfResponsibilityrestriction-
dc.publisherKluwer Academic-
dc.relation.isPartOfBREAST CANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntigens/metabolism-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHBreast Neoplasms/metabolism-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCancer-Associated Fibroblasts/metabolism-
dc.subject.MESHCancer-Associated Fibroblasts/pathology*-
dc.subject.MESHCarcinoma, Ductal, Breast/metabolism-
dc.subject.MESHCarcinoma, Ductal, Breast/pathology*-
dc.subject.MESHCarcinoma, Lobular/metabolism-
dc.subject.MESHCarcinoma, Lobular/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHGelatinases/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMembrane Glycoproteins/metabolism-
dc.subject.MESHMembrane Proteins/metabolism-
dc.subject.MESHProlyl Hydroxylases/metabolism-
dc.subject.MESHProteoglycans/metabolism-
dc.subject.MESHReceptor, Platelet-Derived Growth Factor alpha/metabolism-
dc.subject.MESHReceptor, Platelet-Derived Growth Factor beta/metabolism-
dc.subject.MESHS100 Calcium-Binding Protein A4/metabolism-
dc.subject.MESHSerine Endopeptidases/metabolism-
dc.subject.MESHTissue Array Analysis-
dc.titleExpression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorCheol Keun Park-
dc.contributor.googleauthorWoo Hee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1007/s10549-016-3929-2-
dc.contributor.localIdA03671-
dc.contributor.localIdA00198-
dc.relation.journalcodeJ00403-
dc.identifier.eissn1573-7217-
dc.identifier.pmid27469595-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10549-016-3929-2-
dc.subject.keywordBreast cancer-
dc.subject.keywordCancer-associated fibroblast-
dc.subject.keywordInvasive ductal carcinoma-
dc.subject.keywordInvasive lobular carcinoma-
dc.subject.keywordTumor stroma-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume159-
dc.citation.number1-
dc.citation.startPage55-
dc.citation.endPage69-
dc.identifier.bibliographicCitationBREAST CANCER RESEARCH AND TREATMENT, Vol.159(1) : 55-69, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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