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Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

 Nicholas Collins  ;  Xiaodong Jiang  ;  Ali Zaid  ;  Bethany L. Macleod  ;  Jane Li  ;  Chang Ook Park  ;  Ashraful Haque  ;  Sammy Bedoui  ;  William R. Heath  ;  Scott N. Mueller  ;  Thomas S. Kupper  ;  Thomas Gebhardt  ;  Francis R. Carbone 
 NATURE COMMUNICATIONS, Vol.7 : 11514, 2016 
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Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4(+) T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4(+) T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4(+) T-cell recruitment. Skin CCL5 is derived from CD11b(+) cells and CD8(+) T cells, with the elimination of the latter decreasing CD4(+) T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4(+) memory T cells in skin, which is altered by infection and inflammation history.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
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