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Association between dietary acid load and the risk of cardiovascular disease: nationwide surveys (KNHANES 2008-2011)

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김규리-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author차봉수-
dc.contributor.author한유진-
dc.contributor.author홍남기-
dc.date.accessioned2017-10-26T07:19:30Z-
dc.date.available2017-10-26T07:19:30Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151882-
dc.description.abstractBACKGROUND: Acid-base imbalance has been reported to increase incidence of hypertension and diabetes. However, the association between diet-induced acid load and cardiovascular disease (CVD) risk in the general population has not been fully investigated. METHODS: This was a population-based, retrospectively registered cross-sectional study using nationally representative samples of 11,601 subjects from the Korea National Health and Nutrition Examination Survey 2008-2011. Individual CVD risk was evaluated using atherosclerotic cardiovascular disease (ASCVD) risk equations according to 2013 ACC/AHA guideline assessment in subjects aged 40-79 without prior CVD. Acid-base status was assessed with both the potential renal acid load (PRAL) and the dietary acid load (DAL) scores derived from nutrient intake. RESULTS: Individuals in the highest PRAL tertile had a significant increase in 10 year ASCVD risks (9.6 vs. 8.5 %, P < 0.01) and tended to belong to the high-risk (10 year risk >10 %) group compared to those in the lowest PRAL tertile (odds ratio [OR] 1.23, 95 % confidence interval [CI] 1.22-1.35). The association between higher PRAL score and high CVD risk was stronger in the middle-aged group. Furthermore, a multiple logistic regression analysis also demonstrated this association (OR 1.20 95 % CI 1.01-1.43). Subgroup analysis stratified obesity or exercise status; individuals in unhealthy condition with lower PRAL scores had comparable ASCVD risk to people in the higher PRAL group that were in favorable physical condition. In addition, elevated PRAL scores were associated with high ASCVD risk independent of obesity, exercise, and insulin resistance, but not sarcopenia. Similar trends were observed with DAL scores. CONCLUSION: Diet-induced acid load was associated with increased risk of CVD, independent of obesity and insulin resistance.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcid-Base Equilibrium*-
dc.subject.MESHAcid-Base Imbalance/diagnosis-
dc.subject.MESHAcid-Base Imbalance/epidemiology*-
dc.subject.MESHAcid-Base Imbalance/physiopathology-
dc.subject.MESHAcids/adverse effects*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCardiovascular Diseases/diagnosis-
dc.subject.MESHCardiovascular Diseases/epidemiology*-
dc.subject.MESHCardiovascular Diseases/physiopathology-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHComorbidity-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDiet/adverse effects*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHydrogen-Ion Concentration-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNutrition Assessment-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.titleAssociation between dietary acid load and the risk of cardiovascular disease: nationwide surveys (KNHANES 2008-2011)-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorEugene Han-
dc.contributor.googleauthorGyuri Kim-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorYong?ho Lee-
dc.contributor.googleauthorDong Woo Kim-
dc.contributor.googleauthorHyun Joon Shin-
dc.contributor.googleauthorByung?Wan Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorIn?Kyu Lee-
dc.contributor.googleauthorBong?Soo Cha-
dc.identifier.doi10.1186/s12933-016-0436-z-
dc.contributor.localIdA00322-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA03996-
dc.contributor.localIdA04311-
dc.contributor.localIdA04388-
dc.contributor.localIdA00068-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.relation.journalsince2002~-
dc.identifier.pmid27565571-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordDiet-
dc.subject.keywordEpidemiology-
dc.subject.keywordRisk factors-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Gyuri-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHan, Eu Gene-
dc.contributor.alternativeNameHong, Nam Ki-
dc.contributor.affiliatedAuthorKim, Gyuri-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorHan, Eu Gene-
dc.contributor.affiliatedAuthorHong, Namki-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPage122-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.15(1) : 122, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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