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Sarcopenia of thoracic muscle mass is not a risk factor for survival in lung transplant recipients

Authors
 Seokkee Lee  ;  Hyo Chae Paik  ;  Seok Jin Haam  ;  Chang Young Lee  ;  Kyung Sik Nam  ;  Hee Suk Jung  ;  Young Woo Do  ;  Jee Won Shu  ;  Jin Gu Lee 
Citation
 Journal of Thoracic Disease, Vol.8(8) : 2011-2017, 2016 
Journal Title
 Journal of Thoracic Disease 
ISSN
 2072-1439 
Issue Date
2016
Keywords
Lung transplantation (LTx) ; cross sectional area (CSA) ; sarcopenia ; thoracic muscles
Abstract
BACKGROUND: In lung transplantation (LTx), patients with thoracic muscle sarcopenia may have to require longer to recovery. We measured thoracic muscle volume by using the cross sectional area (CSA) and assessed its effect on early outcomes after LTx. METHODS: A retrospective analysis was conducted to evaluate the effect of thoracic sarcopenia in patients undergoing LTx between January 2010 and July 2015. The lowest CSA quartile (Q1) was defined as sarcopenia. RESULTS: In total, 109 patients were enrolled. The mean CSA was 58.24±15.82 cm(2). Patients in the highest CSA quartile were more likely to be male (92.6% vs. 17.9%, P<0.001), older (55.2±10.1 vs. 43.2±14.9 years, P=0.001), to have a higher body mass index (BMI) (22.3±4.0 vs. 19.4±3.7 kg/m(2), P=0.007), and to have pulmonary fibrosis (85.2% vs. 35.7%, P=0.003) compared with the lowest CSA quartile. Early outcomes including ventilator support duration [32.9±49.2 vs. 24.5±39.9 days, P= not significant (ns)], intensive care unit (ICU) stay duration (28.4±43.7 vs. 24.4±35.9 days, P= ns) and hospital stay duration (61.4±48.2 vs. 50.8±37.2 days, P= ns) tended to be longer in Q1 than Q4, but the difference was not significant. However, the 1-year survival rate was better in Q1 compared with Q4 (66.6% vs. 46.0%, P=0.04). CONCLUSIONS: Although patients with thoracic sarcopenia seem to require a longer post-operative recovery time after LTx, this does not compromise their early outcomes. By contrast, patients with larger thoracic muscle volume (Q4) showed poorer survival times.
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DOI
10.21037/jtd.2016.07.06
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Narm, Kyoung Shik(남경식)
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Suh, Jee Won(서지원) ORCID logo https://orcid.org/0000-0003-0287-0651
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151880
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