Cited 24 times in
Xpert CARBA-R Assay for the Detection of Carbapenemase-Producing Organisms in Intensive Care Unit Patients of a Korean Tertiary Care Hospital
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 정석훈 | - |
dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2017-10-26T07:18:57Z | - |
dc.date.available | 2017-10-26T07:18:57Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151873 | - |
dc.description.abstract | Carbapenemase-producing organisms (CPO) are rapidly disseminating worldwide, and their presence in tertiary care hospitals poses a significant threat to the management of nosocomial infections. There is a need to control CPO, especially in intensive care unit (ICU) patients, because these organisms are resistant to most β-lactam antibiotics and are easily transmitted. At present, the identification of CPO is time-consuming; hence, this study focused on the use of the Xpert CARBA-R assay (Cepheid, USA) to determine intestinal colonization rates of CPO in patients admitted to the ICU of a tertiary care hospital in Korea. Forty clinical stool samples were collected and inoculated both in a CARBA-R cartridge and in conventional culture plates. The CARBA-R assay required only ~one hour to screen CPO, while the time required for conventional culture was over three days. We also found that the prevalences of intestinal colonization by carbapenem-resistant organisms and Enterobacteriaceae were 17.5% (7 out of 40) and 7.5% (3 out of 40), respectively. Among the colonizing strains, three that contained carbapenemase, including Klebsiella pneumonia carbapenemase (KPC), and imipenem (IMP) and Verona integron-mediated metallo-β-lactamase (VIM) were found. With its convenience, the Xpert CARBA-R assay can be included in CPO surveillance strategies | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology | - |
dc.subject.MESH | Bacterial Proteins/genetics* | - |
dc.subject.MESH | Bacterial Proteins/metabolism | - |
dc.subject.MESH | DNA, Bacterial/analysis | - |
dc.subject.MESH | Drug Resistance, Multiple, Bacterial/genetics | - |
dc.subject.MESH | Enterobacteriaceae/drug effects | - |
dc.subject.MESH | Enterobacteriaceae/genetics | - |
dc.subject.MESH | Enterobacteriaceae/isolation & purification* | - |
dc.subject.MESH | Feces/microbiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imipenem/pharmacology | - |
dc.subject.MESH | Intensive Care Units | - |
dc.subject.MESH | Klebsiella pneumoniae/drug effects | - |
dc.subject.MESH | Klebsiella pneumoniae/genetics | - |
dc.subject.MESH | Klebsiella pneumoniae/isolation & purification* | - |
dc.subject.MESH | Reagent Kits, Diagnostic | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Tertiary Healthcare | - |
dc.subject.MESH | beta-Lactamases/genetics* | - |
dc.subject.MESH | beta-Lactamases/metabolism | - |
dc.title | Xpert CARBA-R Assay for the Detection of Carbapenemase-Producing Organisms in Intensive Care Unit Patients of a Korean Tertiary Care Hospital | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Do-Kyun Kim | - |
dc.contributor.googleauthor | Hyoung Sun Kim | - |
dc.contributor.googleauthor | Naina Pinto | - |
dc.contributor.googleauthor | Jongsoo Jeon | - |
dc.contributor.googleauthor | Roshan D’Souza | - |
dc.contributor.googleauthor | Myung Sook Kim | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.identifier.doi | 10.3343/alm.2016.36.2.162 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A03619 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.relation.journalsince | 2012~ | - |
dc.identifier.pmid | 26709264 | - |
dc.relation.journalbefore | ~2011 Korean Journal of Laboratory Medicine (대한진단검사의학회지) | - |
dc.subject.keyword | Carbapenem-resistant organisms | - |
dc.subject.keyword | Carbapenemase-producing organisms | - |
dc.subject.keyword | Colonization | - |
dc.subject.keyword | Intensive care unit | - |
dc.subject.keyword | Xpert CARBA-R | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.citation.volume | 36 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 162 | - |
dc.citation.endPage | 165 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.36(2) : 162-165, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46198 | - |
dc.type.rims | ART | - |
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