Cited 12 times in
Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 송주한 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정경수 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2017-10-26T07:18:09Z | - |
dc.date.available | 2017-10-26T07:18:09Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1176-9106 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151856 | - |
dc.description.abstract | BACKGROUND: Forced expiratory volume in 1 second (FEV1)/forced expiratory volume in 6 seconds (FEV6) has been proposed as an alternative to FEV1/forced vital capacity (FVC) for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction. MATERIALS AND METHODS: We used data obtained in the 5 years of the Fifth and Sixth Korean National Health and Nutrition Examination Survey. A total of 14,978 participants aged ≥40 years who underwent spirometry adequately were the study cohort. ""Airway obstruction"" was a fixed cut-off FEV1/FVC <70% according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. We also used European Respiratory Society/Global Lung Initiative 2012 equations for the FEV1/FVC lower limit of normal. RESULTS: Among the 14,978 participants (43.5% male, 56.5% female; mean age: 56.9 years for men and 57.0 years for women), 14.0% had obstructive lung function according to a fixed cut-off FEV1/FVC <70%. Optimal FEV1/FEV6 cut-off for predicting FEV1/FVC <70% was 75% using receiver operating characteristic curve analyses (area under receiver operating characteristic curve =0.989, 95% confidence interval 0.987-0.990). This fixed cut-off of FEV1/FEV6 showed 93.8% sensitivity, 94.8% specificity, 74.7% positive predictive value, 98.9% negative predictive value, and 0.8 Cohen's kappa coefficient. When compared with FEV1/FVC < lower limit of normal, FEV1/FEV6 <75% tended to over-diagnose airflow limitation (just like a fixed cut-off of FEV1/FVC <70%). When grouped according to age and FEV1 (%), FEV1/FEV6 <75% diagnosed more airway obstruction in older participants and mild-moderate stages compared with FEV1/FVC <70%. CONCLUSION: A valid fixed cut-off for detecting airway obstruction in a Korean population is FEV1/FEV6 of 75%, but should be used with caution in older individuals and those with mild-moderate airway obstruction. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | DOVE Medical Press | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Airway Obstruction/diagnosis* | - |
dc.subject.MESH | Airway Obstruction/physiopathology | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Forced Expiratory Volume* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung/physiopathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nutrition Surveys | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/diagnosis* | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/physiopathology | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Spirometry* | - |
dc.subject.MESH | Vital Capacity* | - |
dc.title | Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population | - |
dc.title.alternative | 한국인에서 폐쇄성폐질환을 진단하기위해 사용되는 FEV1/FVC를 대체할 수 있는 FEV1/FEV6의 기준값 | - |
dc.type | Article | - |
dc.publisher.location | New Zealand | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Kyung Soo Chung | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Joo Han Song | - |
dc.identifier.doi | 10.2147/COPD.S113568 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A02062 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03570 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A00602 | - |
dc.relation.journalcode | J01095 | - |
dc.identifier.eissn | 1178-2005 | - |
dc.identifier.pmid | 27578970 | - |
dc.subject.keyword | airway obstruction | - |
dc.subject.keyword | chronic obstructive pulmonary disease | - |
dc.subject.keyword | forced expiratory volume in 6 seconds | - |
dc.subject.keyword | pulmonary function test | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Song, Joo Han | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Kyung Soo | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Song, Joo Han | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1957 | - |
dc.citation.endPage | 1963 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol.11(1) : 1957-1963, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46181 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.