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Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population

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dc.contributor.author김세규-
dc.contributor.author김영삼-
dc.contributor.author박무석-
dc.contributor.author송주한-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.date.accessioned2017-10-26T07:18:09Z-
dc.date.available2017-10-26T07:18:09Z-
dc.date.issued2016-
dc.identifier.issn1176-9106-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151856-
dc.description.abstractBACKGROUND: Forced expiratory volume in 1 second (FEV1)/forced expiratory volume in 6 seconds (FEV6) has been proposed as an alternative to FEV1/forced vital capacity (FVC) for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction. MATERIALS AND METHODS: We used data obtained in the 5 years of the Fifth and Sixth Korean National Health and Nutrition Examination Survey. A total of 14,978 participants aged ≥40 years who underwent spirometry adequately were the study cohort. ""Airway obstruction"" was a fixed cut-off FEV1/FVC <70% according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. We also used European Respiratory Society/Global Lung Initiative 2012 equations for the FEV1/FVC lower limit of normal. RESULTS: Among the 14,978 participants (43.5% male, 56.5% female; mean age: 56.9 years for men and 57.0 years for women), 14.0% had obstructive lung function according to a fixed cut-off FEV1/FVC <70%. Optimal FEV1/FEV6 cut-off for predicting FEV1/FVC <70% was 75% using receiver operating characteristic curve analyses (area under receiver operating characteristic curve =0.989, 95% confidence interval 0.987-0.990). This fixed cut-off of FEV1/FEV6 showed 93.8% sensitivity, 94.8% specificity, 74.7% positive predictive value, 98.9% negative predictive value, and 0.8 Cohen's kappa coefficient. When compared with FEV1/FVC < lower limit of normal, FEV1/FEV6 <75% tended to over-diagnose airflow limitation (just like a fixed cut-off of FEV1/FVC <70%). When grouped according to age and FEV1 (%), FEV1/FEV6 <75% diagnosed more airway obstruction in older participants and mild-moderate stages compared with FEV1/FVC <70%. CONCLUSION: A valid fixed cut-off for detecting airway obstruction in a Korean population is FEV1/FEV6 of 75%, but should be used with caution in older individuals and those with mild-moderate airway obstruction.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherDOVE Medical Press-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAirway Obstruction/diagnosis*-
dc.subject.MESHAirway Obstruction/physiopathology-
dc.subject.MESHArea Under Curve-
dc.subject.MESHFemale-
dc.subject.MESHForced Expiratory Volume*-
dc.subject.MESHHumans-
dc.subject.MESHLung/physiopathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPulmonary Disease, Chronic Obstructive/diagnosis*-
dc.subject.MESHPulmonary Disease, Chronic Obstructive/physiopathology-
dc.subject.MESHROC Curve-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSpirometry*-
dc.subject.MESHVital Capacity*-
dc.titleCut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population-
dc.title.alternative한국인에서 폐쇄성폐질환을 진단하기위해 사용되는 FEV1/FVC를 대체할 수 있는 FEV1/FEV6의 기준값-
dc.typeArticle-
dc.publisher.locationNew Zealand-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorKyung Soo Chung-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorJoo Han Song-
dc.identifier.doi10.2147/COPD.S113568-
dc.contributor.localIdA00707-
dc.contributor.localIdA01457-
dc.contributor.localIdA02062-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.contributor.localIdA00602-
dc.relation.journalcodeJ01095-
dc.identifier.eissn1178-2005-
dc.identifier.pmid27578970-
dc.subject.keywordairway obstruction-
dc.subject.keywordchronic obstructive pulmonary disease-
dc.subject.keywordforced expiratory volume in 6 seconds-
dc.subject.keywordpulmonary function test-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameSong, Joo Han-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Kyung Soo-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorSong, Joo Han-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Kyung Soo-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage1957-
dc.citation.endPage1963-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol.11(1) : 1957-1963, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46181-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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