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Ultrasonographic Features of Medullary Thyroid Carcinoma: Do they Correlate with Pre and PostOperative Calcitonin Levels?

Authors
 Kyung Eun Cho  ;  Hye Mi Gweon  ;  Ah Young Park  ;  Mi Ri Yoo  ;  JeongAh Kim  ;  Ji Hyun Youk  ;  Young Mi Park  ;  Eun Ju Son 
Citation
 ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, Vol.17(7) : 3357-3362, 2016 
Journal Title
 ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 
ISSN
 1513-7368 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Calcitonin/blood* ; Carcinoma/blood* ; Carcinoma/diagnosis ; Carcinoma/pathology* ; Carcinoma, Neuroendocrine/blood* ; Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/pathology* ; Female ; Humans ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/pathology ; Postoperative Period ; Preoperative Period ; Prognosis ; Retrospective Studies ; Thyroid Neoplasms/blood* ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology* ; Thyroid Nodule/blood ; Thyroid Nodule/diagnosis ; Thyroid Nodule/pathology ; Ultrasonography/methods ; Young Adult
Keywords
Medullary thyroid cancer ; ultrasonographic features ; preoperative calcitonin ; postoperative calcitonin
Abstract
Purpose: To correlate ultrasonographic (US) features of medullary thyroid carcinoma (MTC) with pre operative and postoperative calcitonin levels. Materials and Methods: A total of 130 thyroid nodules diagnosed as MTC were evaluated. Two radiologists retrospectively evaluated preoperative US features according to size, shape, margin, echogenicity, type of calcification, and lymph node status. Postoperative clinical and imaging followup (mean duration 31.9 22.5 months) was performed for detection of tumor recurrence. US features, presence of LN metastasis, and tumor recurrence were compared between MTC nodules with and without elevated preoperative calcitonin (>100 pg/mL). Those with normalized and nonnormalized postoperative calcitonin levels groups were also compared. Results: Common US features of MTCs were solid internal content (90.8%), irregular shape (44.6%), circumscribed margin (46.2%), and hypoechogenicity (56.2%). Comparing MTC nodules with and without elevated preoperative calcitonin levels, the size and shape of MTC nodule and lymph node metastasis showed statistical significance (p<0.05). Postoperative calcitonin normalization correlated with US features of tumor size (p0.002), margin (p0.034), shape (p0.001), and presence of calcification (p0.046). Tumor recurrence and LN metastasis were more prevalent in patients without normalization of postoperative calcitonin than in those with normalization (p0.001). Conclusions: Serum calcitonin measurement is helpful for early diagnosis and predicting prognosis. Postoperative calcitonin measurement is also important for postoperative US follow up, especially in cases with larger nodule size, presence of calcification, irregular shape, and irregular margin.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Gweon, Hye Mi(권혜미) ORCID logo https://orcid.org/0000-0002-3054-1532
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Park, Ah Young(박아영)
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Yoo, Mi Ri(유미리)
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151827
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