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Successful kidney transplantation after desensitization in a patient with positive flow crossmatching and donor-specific anti-HLA-DP antibody: A Case report
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 송승환 | - |
dc.contributor.author | 이주한 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 박금보래 | - |
dc.date.accessioned | 2017-10-26T07:15:29Z | - |
dc.date.available | 2017-10-26T07:15:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151806 | - |
dc.description.abstract | BACKGROUND: Traditionally, the presence of antibodies against human leukocyte antigen (HLA)-C and DP was considered to be associated with only a low risk of antibody-mediated rejection (ABMR) in kidney transplantation (KT), because the antigenicities of these proteins are weak. However, the clinical effects of HLA-C and -DP donor-specific HLA antibodies (DSHAs) have recently been reevaluated. METHODS: Here, we report the case of a retransplant patient with positive flow cytometry crossmatch (FCXM) and high level of HLA-DP DSHA who was desensitized using rituximab, plasmapheresis, and intravenous immunoglobulin. RESULTS: The epitope-based antibody reactivity was identified that the positive B-cell FCXM in our patient was attributable to the specific epitope. The patient underwent a successful retransplantation and has continued to do well for 10 month after KT. CONCLUSION: If an HLA-DP DSHA is present, it is important to detect any mismatched HLA-DP epitope pretransplantation and to monitor HLA-DP levels carefully. According to previous reports, anti-HLA-DP DSHA can induce ABMR soon after transplantation, but such ABMR can be prevented by pretransplantation desensitization and careful monitoring of DSHA levels. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antibodies, Anti-Idiotypic/immunology* | - |
dc.subject.MESH | Blood Grouping and Crossmatching/methods* | - |
dc.subject.MESH | Desensitization, Immunologic/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | HLA-DP Antigens/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation/methods* | - |
dc.title | Successful kidney transplantation after desensitization in a patient with positive flow crossmatching and donor-specific anti-HLA-DP antibody: A Case report | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Seung Hwan Song | - |
dc.contributor.googleauthor | Borae G. Park | - |
dc.contributor.googleauthor | Juhan Lee | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.identifier.doi | 10.1097/MD.0000000000004521 | - |
dc.contributor.localId | A02034 | - |
dc.contributor.localId | A03163 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A01117 | - |
dc.contributor.localId | A01445 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 27512872 | - |
dc.subject.keyword | desensitization | - |
dc.subject.keyword | donor-specific antibody | - |
dc.subject.keyword | HLA-DP antibody | - |
dc.subject.keyword | kidney transplantation | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Song, Seung Hwan | - |
dc.contributor.alternativeName | Lee, Ju Han | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Park, Borae G | - |
dc.contributor.affiliatedAuthor | Song, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Ju Han | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | Park, Borae G | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.citation.volume | 98 | - |
dc.citation.number | 32 | - |
dc.citation.startPage | 4521 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.98(32) : 4521, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45816 | - |
dc.type.rims | ART | - |
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