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N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops

Authors
 Seung Mi Lee  ;  Jong Kwan Jun  ;  Su Ah Kim  ;  Min Ji Kang  ;  Sang Hoon Song  ;  JoonHo Lee  ;  Chan-Wook Park  ;  Joong Shin Park 
Citation
 JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, Vol.42(4) : 380-384, 2016 
Journal Title
 JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 
ISSN
 1341-8076 
Issue Date
2016
MeSH
Adult ; Biomarkers/blood ; Cardiac Output, Low/complications ; Case-Control Studies ; Female ; Fetal Blood/chemistry ; Gestational Age ; Heart Diseases/congenital ; Heart Failure/complications ; Humans ; Hydrops Fetalis/blood* ; Hydrops Fetalis/etiology ; Hydrops Fetalis/mortality ; Infant, Newborn ; Natriuretic Peptide, Brain/blood* ; Peptide Fragments/blood* ; Pregnancy ; Troponin T/blood*
Keywords
N-terminal pro-B-type natriuretic peptide ; cardiac troponin T ; congenital heart disease ; cord blood ; non-immune hydrops
Abstract
AIM: We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops. METHODS: The study population consisted of singleton neonates with non-immune hydrops and healthy control neonates, matched for both gestational age at delivery and mode of delivery. The subjects were divided into three groups: group 1, hydrops of cardiac origin (n=6); group 2, hydrops of non-cardiac origin (n=17); and group 3, control (n=23). The NT-proBNP and cTnT were measured in the cord blood collected at the time of delivery. RESULTS: The median cord blood concentrations of NT-proBNP and cTnT were not different between the hydrops (groups 1 and 2) or control cases. However, the NT-proBNP level was elevated in group 1 compared with groups 2 and 3. The concentrations of cTnT did not differ among the three groups. CONCLUSIONS: The concentration of NT-proBNP was only elevated in cases of hydrops of cardiac origin. Congestive heart failure might not be the underlying mechanism of fluid collection in cases of non-immune hydrops of non-cardiac origin, and NT-proBNP may be a promising tool to differentiate the origin of hydrops.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jog.12920/abstract
DOI
10.1111/jog.12920
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Joon Ho(이준호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151764
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