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Risk assessment and management of post-transplant diabetes mellitus

Authors
 Eugene Han  ;  Myoung Soo Kim  ;  Yu Seun Kim  ;  Eun Seok Kang 
Citation
 Metabolism: Clinical and Experimental, Vol.65(10) : 1559-1569, 2016 
Journal Title
 Metabolism: Clinical and Experimental 
ISSN
 0026-0495 
Issue Date
2016
MeSH
Diabetes Mellitus/diagnosis* ; Diabetes Mellitus/etiology ; Diabetes Mellitus/therapy* ; Humans ; Organ Transplantation/adverse effects* ; Postoperative Complications/diagnosis* ; Postoperative Complications/therapy* ; Risk Assessment* ; Risk Factors
Keywords
Diabetes mellitus ; Management ; Organ transplantation ; Risk factors
Abstract
The success rate of organ transplantation has been increasing with advances in surgical and pharmacological techniques. However, the number of solid organ transplant recipients who require metabolic disease management is also growing. Post-transplant diabetes mellitus (PTDM) is a common complication after solid organ transplantation and is associated with risks of graft loss, cardiovascular morbidity, and mortality. Other risk factors for PTDM include older age, genetic background, obesity, hepatitis C virus infection, hypomagnesemia, and use of immunosuppressant agents (corticosteroids, calcineurin inhibitors, and mammalian target of rapamycin inhibitor). Management of PTDM should be started before the transplantation plan to properly screen high-risk patients. Even though PTDM management is similar to that of general type 2 diabetes, therapeutic approaches must be made with consideration of drug interactions between immunosuppressive agents, glucose-lowering medications, and graft rejection and function.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049516300841
DOI
10.1016/j.metabol.2016.07.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
한유진(Han, Eu Gene)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151761
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