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Junctional bradycardia is a potential risk factor of stroke

DC FieldValueLanguage
dc.contributor.author김광실-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.contributor.author김태훈-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.date.accessioned2017-10-26T07:13:22Z-
dc.date.available2017-10-26T07:13:22Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151758-
dc.description.abstractBACKGROUND: This study aimed to determine the risk of thromboembolic events in patients with junctional bradycardia(JB). METHODS: We retrospectively reviewed electrocardiograms(ECGs) for 380,682 patients. Those with JB on an ECG at least twice over a ≥3-month interval were included for analysis. We additionally included 138 CHADS2 score-matched patients(age, 68.4 ± 15.7 years; male, 52.2%) in sinus rhythm as a control group. Between the JB patients(with or without retrograde P wave) and controls, we compared incidences of ischemic stroke and a composite of ischemic stroke, renal infarction, ischemic colitis, acute limb ischemia, and pulmonary embolism. RESULTS: Among 380,682 patients (age, 47.6 ± 19.9 years; male, 49.3%), 69 patients (age, 68.5 ± 16.5 years; male, 50.7%) exhibited JB on an ECG at least twice over a ≥3-month interval; the overall prevalence of JB was 0.02%. The mean follow-up period was 27.2 ± 26.2 months. Forty-five patients (65.2%) in the JB group had no retrograde P wave. Ischemic stroke incidence was significantly higher in JB patients without a retrograde P wave than in controls (6/45 patients [13.3%] and 3/138 patients [2.2%], respectively; P = 0.007). The incidence of composite thromboembolic events was also significantly higher in JB patients without a retrograde P wave than in controls (8/45 patients [17.8%] and 4/138 patients [2.9%], respectively; P = 0.011). In a Cox proportional hazards model, JB patients without a P wave showed a greater incidence of stroke (hazard ratio, 8.89 [2.20-33.01], P = 0.007) than controls and JB patients with a P wave. CONCLUSIONS: Junctional bradycardia is potentially associated with ischemic stroke, particularly in the absence of an identifiable retrograde P wave.-
dc.description.statementOfResponsibilityopen-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAtrial Fibrillation/diagnosis-
dc.subject.MESHBradycardia/diagnosis*-
dc.subject.MESHBrain Ischemia/diagnosis-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHColitis, Ischemic/diagnosis-
dc.subject.MESHElectrocardiography/methods-
dc.subject.MESHExtremities/blood supply-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHInfarction/diagnosis-
dc.subject.MESHIschemia/diagnosis-
dc.subject.MESHKidney/blood supply-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPulmonary Embolism/diagnosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke/diagnosis*-
dc.subject.MESHThromboembolism/diagnosis-
dc.titleJunctional bradycardia is a potential risk factor of stroke-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorGwang Sil Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorHancheol Lee-
dc.contributor.googleauthorJunbeom Park-
dc.contributor.googleauthorJin-Kyu Park-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorHui-Nam Pak-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.identifier.doi10.1186/s12883-016-0645-9-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.contributor.localIdA01085-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA00315-
dc.relation.journalcodeJ00368-
dc.identifier.eissn1471-2377-
dc.relation.journalsince2001~-
dc.identifier.pmid27457110-
dc.subject.keywordJunctional bradycardia-
dc.subject.keywordStroke-
dc.subject.keywordThromboembolic events-
dc.contributor.alternativeNameKim, Gwang Sil-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.alternativeNameKim, Tae Hoon-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.contributor.affiliatedAuthorKim, Tae-Hoon-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorKim, Gwang Sil-
dc.citation.volume16-
dc.citation.startPage113-
dc.identifier.bibliographicCitationBMC NEUROLOGY, Vol.16 : 113, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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