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Expression of autophagy-related proteins in metastatic breast cancer of different site
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.date.accessioned | 2017-10-26T07:13:14Z | - |
dc.date.available | 2017-10-26T07:13:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151755 | - |
dc.description.abstract | The aim of this study was to evaluate the expression of autophagy-related proteins and their clinical implications in primary and metastatic breast cancer. Immunohistochemical staining of autophagy-related proteins (beclin-1, LC3A, LC3B) in 162 metastatic breast cancers (bone metastasis = 47, brain metastasis = 39, liver metastasis = 24, and lung metastasis = 52) was performed using tissue microarray (TMA). The expression of autophagy-related proteins in tumor cells varied according to metastatic site. Tumoral LC3A expression was high in brain and lung metastasis (P<0.001), stromal LC3A in bone metastasis (P<0.001), and stromal LC3B in liver metastasis (P = 0.017), respectively. In univariate analysis, beclin-1 positivity (P = 0.002) was associated with shorter overall survival (OS). In analysis by metastatic site, beclin-1 positivity (P = 0.002) and activated autophagy status (P = 0.009) in bone metastasis as well as beclin-1 positivity (P = 0.016) and tumoral LC3A positivity (P = 0.038) in lung metastasis were related to shorter OS. In conclusion, the expression of autophagy-related proteins varied according to the site of metastasis and was correlated with prognosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | e-Century Pub. Corp. | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression of autophagy-related proteins in metastatic breast cancer of different site | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Woo-Young Sun | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.localId | A04553 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J01096 | - |
dc.identifier.eissn | 1936-2625 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 7040 | - |
dc.citation.endPage | 7049 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.9(7) : 7040-7049, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45766 | - |
dc.type.rims | ART | - |
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