Hereditary breast and ovarian cancer syndrome accounts for approximately 5% to 10% of breast or ovarian cancers, with which the highpenetrant
BRCA1/2 genes have been associated. With the recent development of next-generation sequencing (NGS), germline mutation
testing and its related medical and surgical management have been rapidly changing. In this review, we summarize the current status and
perspectives of NGS testing for not only BRCA1/2 but also the other breast and ovarian cancer susceptibility genes