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In Vitro Interactions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-Resistant Acinetobacter baumannii

DC FieldValueLanguage
dc.contributor.author정석훈-
dc.date.accessioned2017-10-26T07:09:43Z-
dc.date.available2017-10-26T07:09:43Z-
dc.date.issued2016-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151681-
dc.description.abstractBACKGROUND: Acinetobacter baumannii infections are difficult to treat owing to the emergence of various antibiotic resistant isolates. Because treatment options are limited for multidrug-resistant (MDR) A. baumannii infection, the discovery of new therapies, including combination therapy, is required. We evaluated the synergistic activity of colistin, doripenem, and tigecycline combinations against extensively drug-resistant (XDR) A. baumannii and MDR A. baumannii. METHODS: Time-kill assays were performed for 41 XDR and 28 MDR clinical isolates of A. baumannii by using colistin, doripenem, and tigecycline combinations. Concentrations representative of clinically achievable levels (colistin 2 μg/mL, doripenem 8 μg/mL) and achievable tissue levels (tigecycline 2 μg/mL) for each antibiotic were used in this study. RESULTS: The colistin-doripenem combination displayed the highest rate of synergy (53.6%) and bactericidal activity (75.4%) in 69 clinical isolates of A. baumannii. Among them, the-doripenem-tigecycline combination showed the lowest rate of synergy (14.5%) and bactericidal activity (24.6%). The doripenem-tigecycline combination showed a higher antagonistic interaction (5.8%) compared with the colistin-tigecycline (1.4%) combination. No antagonism was observed for the colistin-doripenem combination. CONCLUSIONS: The colistin-doripenem combination is supported in vitro by the high rate of synergy and bactericidal activity and lack of antagonistic reaction in XDR and MDR A. baumannii. It seems to be necessary to perform synergy tests to determine the appropriate combination therapy considering the antagonistic reaction found in several isolates against the doripenem-tigecycline and colistin-tigecycline combinations. These findings should be further examined in clinical studies.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfAnnals of Laboratory Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcinetobacter Infections/drug therapy-
dc.subject.MESHAcinetobacter Infections/microbiology-
dc.subject.MESHAcinetobacter baumannii/drug effects*-
dc.subject.MESHAcinetobacter baumannii/genetics-
dc.subject.MESHAcinetobacter baumannii/isolation & purification-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use-
dc.subject.MESHBacterial Proteins/genetics-
dc.subject.MESHCarbapenems/pharmacology*-
dc.subject.MESHCarbapenems/therapeutic use-
dc.subject.MESHColistin/pharmacology*-
dc.subject.MESHColistin/therapeutic use-
dc.subject.MESHDrug Resistance, Multiple, Bacterial/drug effects*-
dc.subject.MESHDrug Synergism-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHHumans-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMinocycline/analogs & derivatives*-
dc.subject.MESHMinocycline/pharmacology-
dc.subject.MESHMinocycline/therapeutic use-
dc.subject.MESHMultilocus Sequence Typing-
dc.subject.MESHbeta-Lactamases/genetics-
dc.titleIn Vitro Interactions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-Resistant Acinetobacter baumannii-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorGyun Cheol Park-
dc.contributor.googleauthorJi Ae Choi-
dc.contributor.googleauthorSook Jin Jang-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorChoon-Mee Kim-
dc.contributor.googleauthorIn Sun Choi-
dc.contributor.googleauthorSeong Ho Kang-
dc.contributor.googleauthorGeon Park-
dc.contributor.googleauthorDae Soo Moon-
dc.identifier.doi10.3343/alm.2016.36.2.124-
dc.contributor.localIdA03619-
dc.relation.journalcodeJ00164-
dc.relation.journalsince2012~-
dc.identifier.pmid26709259-
dc.relation.journalbefore~2011 Korean Journal of Laboratory Medicine (대한진단검사의학회지)-
dc.subject.keywordAcinetobacter baumannii-
dc.subject.keywordAntagonism-
dc.subject.keywordColistin-
dc.subject.keywordDoripenem-
dc.subject.keywordExtensively drug-resistant-
dc.subject.keywordSynergism-
dc.subject.keywordTigecycline-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.citation.volume36-
dc.citation.number2-
dc.citation.startPage124-
dc.citation.endPage130-
dc.identifier.bibliographicCitationAnnals of Laboratory Medicine, Vol.36(2) : 124-130, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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