Cited 13 times in
High-grade squamous intraepithelial lesion arising adjacent to vulvar lymphangioma circumscriptum: a tertiary institutional experience
DC Field | Value | Language |
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dc.contributor.author | 김현수 | - |
dc.date.accessioned | 2017-10-26T07:09:32Z | - |
dc.date.available | 2017-10-26T07:09:32Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151677 | - |
dc.description.abstract | Lymphangioma circumscriptum of the vulva occurs in patients who have undergone radical hysterectomy, lymph node dissection, or radiation therapy for management of advanced uterine cancer. Since vulvar lymphangioma circumscriptum typically presents as multiple, grossly verrucous vesicles of various sizes, it may be impossible to clinically distinguish vulvar lymphangioma circumscriptum from other vulvoperineal cutaneous diseases. In the present study, 16 (1.6%) out of the 1,024 vulvar biopsy or excision specimens were diagnosed as lymphangioma circumscriptum. In two (12.5%) out of the 16 cases, unusual histopathological findings were observed. Both patients had previously undergone radical hysterectomy with lymph node dissection and postoperative radiation therapy or concurrent chemoradiation therapy for advanced cervical cancer. Microscopic examination revealed high-grade squamous intraepithelial lesions, which were located immediately adjacent to the normal squamous epithelium covering the dilated subepithelial lymphatic vessels. Further, human papillomavirus genotyping confirmed that both patients were infected with high-risk human papillomavirus. High-grade squamous intraepithelial lesion cannot be grossly distinguished from vulvar lymphangioma circumscriptum because the multiple, verrucous vesicles that constitute the characteristic gross appearance of vulvar lymphangioma circumscriptum hinder its distinction. In this regard, our cases of high-grade squamous intraepithelial lesion, located adjacent to vulvar lymphangioma circumscriptum, support the notion that active surgical excision is necessary for the treatment of vulvar lymphangioma circumscriptum | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphangioma/pathology* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Tertiary Care Centers | - |
dc.subject.MESH | Vulvar Neoplasms/pathology* | - |
dc.subject.MESH | Young Adult | - |
dc.title | High-grade squamous intraepithelial lesion arising adjacent to vulvar lymphangioma circumscriptum: a tertiary institutional experience | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Go Eun Bae | - |
dc.contributor.googleauthor | Gun Yoon | - |
dc.contributor.googleauthor | Yong Jung Song | - |
dc.contributor.googleauthor | Hyun-Soo Kim | - |
dc.identifier.doi | 10.18632/oncotarget.10158 | - |
dc.contributor.localId | A01114 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27329721 | - |
dc.subject.keyword | high-grade squamous intraepithelial lesion | - |
dc.subject.keyword | human papillomavirus | - |
dc.subject.keyword | lymphangioma circumscriptum | - |
dc.subject.keyword | vulva | - |
dc.contributor.alternativeName | Kim, Hyun-Soo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Soo | - |
dc.citation.volume | 7 | - |
dc.citation.number | 30 | - |
dc.citation.startPage | 48120 | - |
dc.citation.endPage | 48129 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, Vol.7(30) : 48120-48129, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45691 | - |
dc.type.rims | ART | - |
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