Cited 29 times in
Advanced Left Atrial Remodeling and Appendage Contractile Dysfunction in Women Than in Men Among the Patients With Atrial Fibrillation: Potential Mechanism for Stroke
DC Field | Value | Language |
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dc.contributor.author | 김태훈 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 홍그루 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 심지영 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 유희태 | - |
dc.date.accessioned | 2017-10-26T07:09:04Z | - |
dc.date.available | 2017-10-26T07:09:04Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151668 | - |
dc.description.abstract | BACKGROUND: The risk of stroke imposed by atrial fibrillation (AF) is significantly greater in women than men; however, the mechanism remains elusive. We hypothesized that left atrial (LA) remodeling and poor contractile function of LA appendage (LAA) would be more predominant in women than men among AF patients. METHODS AND RESULTS: A total of 579 AF patients (216 women vs age-, AF type-, and incidences of heart failure, hypertension, diabetes mellitus, stroke or transient ischemic attack, and vascular disease-matched 363 men, 61.3±10.2 years old, 70.1% paroxysmal AF) who underwent AF catheter ablation were included. Sex differences in LA volume index (LAVI) and LAA emptying flow velocity (FV) were analyzed in risk factor 0, 1, and ≥2 groups, according to their CHA2DS2-VASc scores beyond sex category. LAA-FV was more significantly reduced in women with risk factor ≥2 than in men of the same risk group (P=0.022). Women showed greater LAVI than their male counterparts in the risk factor ≥2 group (P<0.001). The majority of female patients with a history of stroke had a large LAVI and low LAA-FV (P<0.001); however, no such distribution was observed in men (P=0.596). LA volume index (odds ratio [OR], 1.038; 95% CI, 1.003-1.075, P=0.035) or LAA-FV (OR, 0.976; 95% CI, 0.952-0.999; P=0.047) was significantly associated with a history of stroke in women. CONCLUSIONS: More-extensive LA remodeling and deterioration in LAA function were noted in women than in men with high calculated risk of stroke in AF. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrial Appendage/diagnostic imaging | - |
dc.subject.MESH | Atrial Appendage/physiopathology* | - |
dc.subject.MESH | Atrial Fibrillation/complications | - |
dc.subject.MESH | Atrial Fibrillation/diagnostic imaging | - |
dc.subject.MESH | Atrial Fibrillation/physiopathology* | - |
dc.subject.MESH | Atrial Fibrillation/surgery | - |
dc.subject.MESH | Atrial Remodeling/physiology* | - |
dc.subject.MESH | Catheter Ablation | - |
dc.subject.MESH | Echocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imaging, Three-Dimensional | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Contraction/physiology* | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Stroke/etiology | - |
dc.subject.MESH | Stroke/physiopathology* | - |
dc.subject.MESH | Stroke/prevention & control | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Advanced Left Atrial Remodeling and Appendage Contractile Dysfunction in Women Than in Men Among the Patients With Atrial Fibrillation: Potential Mechanism for Stroke | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Jihei Sara Lee | - |
dc.contributor.googleauthor | Tae?Hoon Kim | - |
dc.contributor.googleauthor | Jae?Sun Uhm | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Geu?Ru Hong | - |
dc.contributor.googleauthor | Moon?Hyoung Lee | - |
dc.contributor.googleauthor | Chi Young Shim | - |
dc.contributor.googleauthor | Hui?Nam Pak | - |
dc.identifier.doi | 10.1161/JAHA.116.003361 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A04386 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02213 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02535 | - |
dc.contributor.localId | A01085 | - |
dc.relation.journalcode | J01774 | - |
dc.identifier.eissn | 2047-9980 | - |
dc.identifier.pmid | 27402232 | - |
dc.identifier.url | https://www.ahajournals.org/doi/10.1161/JAHA.116.003361 | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | remodeling | - |
dc.subject.keyword | sex | - |
dc.subject.keyword | stroke | - |
dc.contributor.alternativeName | Kim, Tae Hoon | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.alternativeName | Hong, Geu Ru | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Shim, Chi Young | - |
dc.contributor.alternativeName | Uhm, Jae Sun | - |
dc.contributor.alternativeName | Yu, Hee Tae | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Hong, Geu Ru | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Shim, Chi Young | - |
dc.contributor.affiliatedAuthor | Uhm, Jae Sun | - |
dc.contributor.affiliatedAuthor | Yu, Hee Tae | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hoon | - |
dc.citation.volume | 5 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 003361 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.5(7) : 003361, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45682 | - |
dc.type.rims | ART | - |
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