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Effects of intraoperative inhaled iloprost on primary graft dysfunction after lung transplantation: A retrospective single center study

DC FieldValueLanguage
dc.contributor.author김남오-
dc.contributor.author오영준-
dc.contributor.author유영철-
dc.contributor.author이수현-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author김현주-
dc.contributor.author백효채-
dc.date.accessioned2017-10-26T07:08:03Z-
dc.date.available2017-10-26T07:08:03Z-
dc.date.issued2016-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151646-
dc.description.abstractDESIGN: Inhaled iloprost was known to alleviate ischemic-reperfusion lung injury. We investigated whether intraoperative inhaled iloprost can prevent the development of primary graft dysfunction after lung transplantation. Data for a consecutive series of patients who underwent lung transplantation with extracorporeal membrane oxygenation were retrieved. By propensity score matching, 2 comparable groups of 30 patients were obtained: patients who inhaled iloprost immediately after reperfusion of the grafted lung (ILO group); patients who did not receive iloprost (non-ILO group). RESULTS: The severity of pulmonary infiltration on postoperative days (PODs) 1 to 3 was significantly lower in the ILO group compared to the non-ILO group. The PaO2/FiO2 ratio was significantly higher in the ILO group compared to the non-ILO group (318.2 ± 74.2 vs 275.9 ± 65.3?mm Hg, P = 0.022 on POD 1; 351.4 ± 58.2 vs 295.8 ± 53.7?mm Hg, P = 0.017 on POD 2; and 378.8 ± 51.9 vs 320.2 ± 66.2?mm Hg, P = 0.013 on POD 3, respectively). The prevalence of the primary graft dysfunction grade 3 was lower in the ILO group compared to the non-ILO group (P = 0.042 on POD 1; P = 0.026 on POD 2; P = 0.024 on POD 3, respectively). The duration of ventilator use and intensive care unit were significantly reduced in the ILO group (P = 0.041 and 0.038). CONCLUSIONS: Intraoperative inhaled iloprost could prevent primary graft dysfunction and preserve allograft function, thus reducing the length of ventilator care and intensive care unit stay, and improving the overall early post-transplant morbidity in patients undergoing lung transplantation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Inhalation-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIloprost/administration & dosage*-
dc.subject.MESHIntraoperative Care*-
dc.subject.MESHLung Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHPrimary Graft Dysfunction/prevention & control*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHVasodilator Agents/administration & dosage*-
dc.titleEffects of intraoperative inhaled iloprost on primary graft dysfunction after lung transplantation: A retrospective single center study-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorSu Hyun Lee-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorChang Yeong Lee-
dc.contributor.googleauthorNamo Kim-
dc.contributor.googleauthorMin-Yung Chang-
dc.contributor.googleauthorYoung-Chul You-
dc.contributor.googleauthorHyun Joo Kim-
dc.contributor.googleauthorHyo Chae Paik-
dc.contributor.googleauthorYoung Jun Oh-
dc.identifier.doi10.1097/MD.0000000000003975-
dc.contributor.localIdA02389-
dc.contributor.localIdA02484-
dc.contributor.localIdA02897-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.contributor.localIdA01135-
dc.contributor.localIdA01846-
dc.contributor.localIdA00356-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid27399072-
dc.subject.keywordiloprost-
dc.subject.keywordlung transplantation-
dc.subject.keywordprimary graft dysfunction-
dc.contributor.alternativeNameKim, Namo-
dc.contributor.alternativeNameOh, Young Jun-
dc.contributor.alternativeNameYoo, Young Chul-
dc.contributor.alternativeNameLee, Su Hyun-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.alternativeNameKim, Hyun Zu-
dc.contributor.alternativeNamePaik, Hyo Chae-
dc.contributor.affiliatedAuthorOh, Young Jun-
dc.contributor.affiliatedAuthorYoo, Young Chul-
dc.contributor.affiliatedAuthorLee, Su Hyun-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.contributor.affiliatedAuthorKim, Hyun Joo-
dc.contributor.affiliatedAuthorPaik, Hyo Chae-
dc.contributor.affiliatedAuthorKim, Namo-
dc.citation.volume95-
dc.citation.number27-
dc.citation.startPage3975-
dc.identifier.bibliographicCitationMEDICINE, Vol.95(27) : 3975, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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